NDLI: Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carpenter, C. B. Merrill, J. P. Strom, T. B. Deisseroth, A. Morganroth, J.
Abstract	The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3':5'-cyclic AMP: prostaglandin E(1), cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	69
Language	English
Publisher	National Academy of Sciences
Publisher Date	1972-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenylate Cyclase Metabolism Isoantigens Lymphocytes Drug Effects Parasympathomimetics Pharmacology Acetylcholine Animals Butyrates Carbachol Cholera Cyclic AMP Enzyme Activation Immunology Prostaglandins Rats, Inbred BN Rats, Inbred Lew Receptors, Cholinergic Skin Transplantation Spleen Theophylline Thymus Gland Toxins, Biological Transplantation Immunology Transplantation, Homologous Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase.