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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Deangelo, A. B. Fujimoto, G. I. |
| Abstract | The rate of leucine incorporation into a specific estrogen-induced protein of immature rat isolated by gel electrophoresis declines rapidly between 2-4 hr after estrogen stimulation in vivo followed by incubation in vitro. Actinomycin D present during the in vitro phase prevents this decline, and elicits a 'superinduction' effect at 2 hr. Labeled induced protein remains stable during this time period, indicating that its decline is due to a reduction in synthesis capacity for the inducible protein, rather than to its degradation. A second injection of hormone at 3 hr has no effect on the reduced level of synthesis capacity for induced protein noted at 4 hr in the rat uterus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 70 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1973-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Estradiol Pharmacology Protein Biosynthesis Drug Effects Uterus Metabolism Animals Carbon Isotopes Dactinomycin Electrophoresis, Polyacrylamide Gel Kinetics Leucine Proteins Isolation & Purification Stimulation, Chemical Tritium Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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