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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Alvares, A. P. Bickers, D. R. Kappas, A. |
| Abstract | The CO-difference spectrum of microsomes from rats treated with the polychlorinated biphenyls mixture, Aroclor 1254, has an absorption maximum at 448 nm. With ethylisocyananide as the ligand for reduced microsomes, Aroclor 1254 treatment causes a shift in the 455-nm peak to 453 nm and increases the ratio of absorbance of 455 nm to that at 430 nm from 0.53, obtained with untreated rats, to 1.24. These findings are similar to those seen in rats treated with the polycyclic hydrocarbon, 3-methylcholanthrene, but differ from those that characterize cytochrome P-450 in control or phenobarbital-treated rats. Aroclor 1254 treatment results in a tripling of cytochrome P-448 content and a 10-fold increase in benzo-[a]pyrene hydroxylation. However-unlike 3-methylcholanthrene, but like the phenobarbital type of inducing agents-Aroclor 1254 treatment causes a significant enhancement of ethylmorphine N-demethylase. These data suggest that Aroclor 1254-induced cytochrome P-448 may be catalytically different from the 3-methylcholanthrene-induced P-448 or that the hemoprotein(s) induced by Aroclor 1254 may be a mixture of cytochromes P-448 and P-450 exhibiting catalytic properties of both cytochromes. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 5 |
| Volume Number | 70 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1973-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cytochromes Biosynthesis Microsomes, Liver Enzymology Polychlorinated Biphenyls Pharmacology Animals Benzopyrenes Carbon Monoxide Cytochrome P-450 Enzyme System Dactinomycin Enzyme Induction Ligands Methylcholanthrene Mixed Function Oxygenases Morphinans Nitriles Oxidoreductases, N-Demethylating Phenobarbital Spectrophotometry Stimulation, Chemical Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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