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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Niall, H. D. Aurbach, G. D. Sauer, R. T. Jacobs, J. W. Keutmann, H. T. Potts, J. T. O'riordan, J. L. Segre, G. V. |
| Abstract | The sequence of the amino-terminal 37 residues of human parathyroid hormone has been established. The hormone used in these studies was isolated in highly purified form from parathyroid adenomata and was subjected to automated degradation in a Beckman sequencer. A high-sensitivity sequencing procedure employing (35)S-labeled phenylisothiocyanate of high specific activity as the coupling agent was used. The sequence obtained differs from that of bovine parathyroid hormone in three of the first 37 positions, and from that of porcine parathyroid hormone in two positions. A single human-specific residue was found (asparagine 16). The sequence obtained differs at three positions (22, 28, and 30) from the structure for human parathyroid hormone reported recently by Brewer et al. [(1972) Proc. Nat. Acad. Sci. USA 69, 3585-3588] and synthesized by Andreatta et al. [(1973) Helv. Chim. Acta, 56, 470-473] We have carefully reviewed our data, reported here in detail, on the sequence positions in dispute. We must conclude, on the basis of all available data, that the structure that we propose is the correct structure. The objective resolution of these discrepancies in structural analysis through further chemical and immunochemical studies is important, since synthesis of human parathyroid hormone, in which there is widespread interest for physiological and clinical studies, must be based on the correct sequence of the human hormone if the peptide is to be genuinely useful. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 71 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1974-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Parathyroid Hormone Adenoma Amino Acid Sequence Animals Autoanalysis Chromatography, Gel Chromatography, Ion Exchange Chromatography, Thin Layer Cyanogen Bromide Hydrolysis Iodine Radioisotopes Isolation & Purification Sulfur Radioisotopes Swine Thiohydantoins Comparative Study Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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