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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ham, E. A. Kuehl, F. A. Cirillo, V. J. Zanetti, M. E. |
| Abstract | Endogenous uterine prostaglandin levels were monitored in the cycling rat and prostaglandins of the F-type were found to rise at proestrus when estrogen levels have been shown to be maximal. Evidence that this is an estrogen-induced event is furnished by the finding that estradiol-17beta caused a similar rise in prostaglandin F levels in uteri of ovariectomized rats, an action blocked by coadministration of progesterone. Examination of in vitro prostaglandin synthetase by uterine microsomal fractions from cycling rats and estrogen-treated ovariectomized rats revealed that the action of estrogen to control prostaglandin synthesis in a directional manner is accomplished, at least in part, by regulation of the prostaglandin synthetase complex, resulting in a patterned alteration in the ratio of prostaglandin F to prostaglandin E. These results demonstrate that prostaglandins are involved in the expression of estrogen action in the rat uterus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 72 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1975-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Estrogens Pharmacology Prostaglandins Biosynthesis Uterus Metabolism Animals Castration Cyclic AMP Cyclic GMP Diestrus Estradiol Estrus Indomethacin Microsomes Ovary Physiology Pregnancy Proestrus Progesterone Prostaglandin-Endoperoxide Synthases Prostaglandins F Time Factors Drug Effects Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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