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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sakmann, B. Neher, E. |
| Abstract | Membrane currents from voltage-clamped frog muscle fibers were recorded during iontophoretic application of steady doses of carbachol, acetylcholine, and suberyldicholine to the endplate region. In the presence of these drugs, an exponentially relaxing current was observed after step changes of membrane potential. The time constant of relaxation was found to be voltage-dependent. It was equal to the time constant obtained from the autocorrelation function of drug-induced conductance fluctuations measured under similar conditions. Analysis of instantaneous current at the on- and offsets of voltageclamp pulses showed that there is no shift in equilibrium potential during the pulses. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 72 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1975-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Pharmacology Carbachol Choline Neuromuscular Junction Drug Effects Animals Anura Analogs & Derivatives Dicarboxylic Acids Electric Conductivity Iontophoresis Mathematics Membrane Potentials Physiology Rana Esculenta Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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