NDLI: Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata).

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1978 Volume: 75 Issue: 12

Year: 1978 Volume: 75 Issue: 11

Year: 1978 Volume: 75 Issue: 10

Year: 1978 Volume: 75 Issue: 9

Year: 1978 Volume: 75 Issue: 8

Year: 1978 Volume: 75 Issue: 7

Year: 1978 Volume: 75 Issue: 6

Year: 1978 Volume: 75 Issue: 5

Year: 1978 Volume: 75 Issue: 4

Year: 1978 Volume: 75 Issue: 3

Year: 1978 Volume: 75 Issue: 2

Biochemistry of actomyosin-dependent cell motility (a review).

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

Blockade of neuromuscular transmission by enzymatically active and inactive beta-bungarotoxin.

An RNA transcribed from DNA at the origin of phage fd single strand to replicative form conversion.

Characterization of pro-opiocortin, a precursor to opioid peptides and corticotropin.

In vitro synthesis of vesicular stomatitis virus membrane glycoprotein and insertion into membranes.

Triphosphate residues at the 5' ends of rRNA precursor and 5S RNA from Dictyostelium discoideum.

Direct fluorescent assay of urokinase and plasminogen activators of normal and malignant cells: kinetics and inhibitor profiles.

Oligosaccharide chains are trimmed during synthesis of the envelope glycoprotein of vesicular stomatitis virus.

Alteration of the physicochemical properties of triphosphoinositide by nicotinic ligands.

Structure of a poly (adenosine diphosphoribose) monomer: 2'-(5'-hosphoribosyl)-5'-adenosine monophosphate.

Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products.

Erythrocyte membrane abnormalities in Duchenne muscular dystrophy monitored by saturation transfer electron paramagnetic resonance spectroscopy.

Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities.

Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides.

Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer.

Antibody response of mice to chemically induced tumors.

Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes.

Control of aldosterone secretion during sodium restriction: adrenal receptor regulation and increased adrenal sensitivity to angiotensin II.

Extrahypophysial distribution of corticotropin as a function of brain size.

Infection of mouse preimplantation embryos with simian virus 40 and polyoma virus.

Interaction of human chorionic gonadotropin with membrane components of rat testes.

Role of anions in parathyroid hormone release from dispersed bovine parathyroid cells.

Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa cells observed by high-resolution 31P nuclear magnetic resonance.

Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata).

Electrophysiological analysis reinnervation of transplants in the anterior chamber of the eye by the autonomic ground plexus of the iris.

Autoradiographic localization of gamma-aminobutyric acid receptors in the rat central nervous system by using [3H]muscimol.

Photoperiodic regulation of the hamster testis: dependence on circadian rhythms.

Inhibition of putrescine synthesis blocks development of the polychete Ophryotrocha labronica at gastrulation.

The molecular mechanism of excitation in visual transduction and bacteriorhodopsin.

On the formation of protein tertiary structure on a computer.

Respective roles of short- and long-range interactions in protein folding.

Model compounds for the T state of hemoglobin.

Picosecond photodissociation and subsequent recombination processes in carbon monoxide hemoglobin.

Search for relationships among the hemolytic, phospholipolytic, and neurotoxic activities of snake venoms.

Analysis of the phiX DNA replication cycle by electron microscopy.

On the physical basis for ambiguity in genetic coding interactions.

Nucleotide sequence of an insertion element, IS1.

Two regions of the adenovirus 2 genome specify families of late polysomal RNAs containing common sequences.

Identification of precursor molecules to individual tRNA species from Bombyx mori.

How many base-pairs per turn does DNA have in solution and in chromatin? Some theoretical calculations.

Translational control: recognition of the methylated 5' end and an internal sequence in eukaryotic mRNA by the initiation factor that binds methionyl-tRNAfMet.

Accumulation of a slowly dissociable peptide hormone binding component by isolated target cells.

Displacement-loop replication initiation sequence in animal mitochondrial DNA exists as a family of discrete lengths.

Preferential transcription of the ovalbumin gene in isolated hen oviduct nuclei by RNA polymerase B.

Amino acid sequence of honeybee prepromelittin synthesized in vitro.

Chromatin structure in the cellular slime mold Dictyostelium discoideum.

Discrete length classes of DNA depend on mode of dehydration.

Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

Translation of rat liver fatty acid synthetase mRNA in a cell-free system derived from wheat germ.

Human mitochondrial DNA: analysis of 7S DNA from the origin of replication.

Regulation of protein synthesis in rabbit reticulocyte lysates by the heme-regulated protein kinase: Inhibition of interaction of $Met-tRNA_{f}^{Met}$ binding factor with another initiation factor in formation of $Met-tRNA_{f}^{Met}·40S$ ribosomal subunit complexes

Immunization of rats with polypeptide chains from torpedo acetylcholine receptor causes an autoimmune response to receptors in rat muscle.

Construction and characterization of an Escherichia coli plasmid bearing a functional gene G of bacteriophage phiX174.

Ligand-promoted transfer of proteins between phases: spontaneous and electrically helped.

Effect of hemin on site-specific phosphorylation of eukaryotic initiation factor 2.

Repair of depurinated DNA in vitro by enzymes purified from human lymphoblasts.

Regulation of transcription of the late genes of bacteriophage T7.

Thymic hormone-like restoration by human prealbumin of azathioprine sensitivity of spleen cells from thymectomized mice.

Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

Production a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum.

Correlation between phosphorylated H1 histones and satellite DNAs in Drosophila virilis.

Egg surface glycoprotein receptor for sea urchin sperm bindin.

Regulation of the self-renewal probability in Hydra stem cell clones.

Growth and maintenance of HeLa cells in serum-free medium supplemented with hormones.

EcoRI cleavage site variants of mitochondrial DNA molecules from rats.

Theoretical study of genetic variability, assuming stepwise production of neutral and very slightly deleterious mutations.

Incomplete dosage compensation in an evolving Drosophila sex chromosome.

Expression of human adenosine deaminase after fusion of adenosine deaminase-deficient cells with mouse fibroblasts.

Assignment of genes to regions of mouse chromosomes.

Control of antibody heterogeneity in strain 2 guinea pigs.

Murine complement component 3: genetic variation and linkage to H-2.

Erythroid colony formation from human fetal liver.

Homology-dependent cutting in trans of DNA in extracts of Escherichia coli: an approach to the enzymology of genetic recombination.

Fluorine-19 nuclear magnetic resonance studies of Escherichia coli membranes.

On the process of cellular division in Escherichia coli: a series of mutants of E. coli altered in the penicillin-binding proteins.

Interaction of mycobacterial polymethylpolysaccharides with paranaric acid and palmitoyl-coenzyme A: structural specificity and monomeric dissociation constants.

Escherichia coli dnaB mutant defective in DNA initiation: isolation and properties of the dnaB protein.

Nascent peptide as sole attachment of polysomes to membranes in bacteria.

Molecular cytochemistry: incorporation of fluorescently labeled actin into living cells.

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.

Affinity filters, a new approach to the isolation of tox mutants of Vibrio cholerae.

Dense plexus of substance P immunoreactive nerve terminals in eminentia medialis of the primate hypothalamus.

Nonequivalence of alpha-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons.

Conformational changes of the chromatin subunit.

Stimulation of bilirubin catabolism in jaundiced Gunn rats by an induced of microsomal mixed-function monooxygenases.

Antibody-mediated activation of a defective beta-D-galactosidase: dimeric form of the activatable mutant enzyme.

In vitro transcription of heat-shock-specific RNA from chromatin of Drosophila melanogaster cells.

Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype.

Endogenous New World primate type C viruses isolated from owl monkey (Aotus trivirgatus) kidney cell line.

Genetic recombination between mouse type C RNA viruses: a mechanism for endogenous viral gene amplification in mammalian cells.

Year: 1978 Volume: 75 Issue: 1

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bagwell, C. B. Lehotay, D. C. Block, N. L. Lo, T. M. Levey, G. S. Claflin, A. J. Vesely, D. L. Fletcher, M. A. Hudson, J. L.
Abstract	We have recently described the presence of a guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] inhibitor (GCI) in an aqueous extract of the balsam pear (Momordica charantia abbreviata). Because the guanylate cyclase-cyclic GMP system is though to be involved in cell growth, DNA and RNA synthesis, and possible malignant transformation, we examined the effect of the aqueous extract containing GCI on an undifferentiated adenocarcinoma of the rat prostate and concanavalin-A-stimulated [3H]thymidine incorporation into cultured splenic lymphocytes, a process thought to be mediated by cyclic GMP. The results demonstrate that the extract of the balsam pear blocks both the growth of the rat prostatic adencarcinoma in vitro and [3H]thymidine incorporation into DNA. DNA histograms from flow cytometry indicated that the extract containing GCI inhibited in the G2 + M phase of the cell cycle, a presumed locus of cyclic GMP effects. In addition, guanylate cyclase activity was significantly greater in the tumor than normal prostate tissue and was decreased by the extract containing GCI. Cyclic GMP levels in the tumor in culture wer also decreased by addition of the extract. It remains to be determined whether or not the anti-tumor agent and GCI are the same substance.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	75
Language	English
Publisher	National Academy of Sciences
Publisher Date	1978-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenocarcinoma Drug Therapy Guanylate Cyclase Antagonists & Inhibitors Plant Extracts Pharmacology Prostatic Neoplasms Enzymology Animals Cell Cycle Concanavalin A Cyclic GMP Metabolism In Vitro Techniques Neoplasms, Experimental Thymidine Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in