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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Novogrodsky, A. Quittner, S. Stenzel, K. H. Rubin, A. L. |
| Abstract | Transglutaminase activity is present in human peripheral lymphocytes and is enhanced up to 15-fold within 10-30 min after treatment of the cells with concanavalin A. Phytohemagglutinin has a similar effect. The enzyme is not detected when intact cells are assayed; it is detected only in cell lysates. Concanavalin A enhances transglutaminase activity only when it is incubated with intact cells; concanavalin A treatment of cell lysates has no effect, alpha-Methyl-D-mannoside specifically inhibits the enhancement of transglutaminase activity in cells treated with concanavalin A results from the specific interaction of the lectin with its saccharide binding site on the cell surface, rather than by direct interaction with the enzyme itself. The increased activity of transglutaminase in cells treated with concanavalin A, as compared to unstimulated cells, is maintained under assay conditions in which saturating levels of Ca2+ are present. Transglutaminase may be involved in early cellular events leading to lymphocyte blastogenesis. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 3 |
| Volume Number | 75 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1978-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Lymphocyte Activation Lymphocytes Enzymology Gamma-Glutamyltransferase Blood Animals Cell Line Concanavalin A Pharmacology Cycloheximide Dose-Response Relationship, Drug Enzyme Activation Kinetics Lectins Macrophages Methylmannosides Mice Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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