NDLI: Low and high density lipoproteins and chylomicrons as regulators of rate of cholesterol synthesis in rat liver in vivo.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1979 Volume: 76 Issue: 12

Year: 1979 Volume: 76 Issue: 11

Year: 1979 Volume: 76 Issue: 10

Year: 1979 Volume: 76 Issue: 9

Year: 1979 Volume: 76 Issue: 8

Year: 1979 Volume: 76 Issue: 7

Year: 1979 Volume: 76 Issue: 6

Year: 1979 Volume: 76 Issue: 5

Year: 1979 Volume: 76 Issue: 4

Year: 1979 Volume: 76 Issue: 3

Year: 1979 Volume: 76 Issue: 2

Year: 1979 Volume: 76 Issue: 1

Activation of high levels of endogenous phospholipase A2 in cultured cells.

Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.

Human heavy chain disease protein WIS: implications for the organization of immunoglobulin genes.

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

Assembly of the mitochondrial membrane system: partial sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae.

Calcium-sensitive regulation of actin-myosin interactions in baby hamster kidney (BHK-21) cells.

Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast.

Bovine kidney 3-methylcrotonyl-CoA and propionyl-CoA carboxylases: each enzyme contains nonidentical subunits.

Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets.

DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites.

Definition of cytochrome c binding domains by chemical modification: kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain.

Low and high density lipoproteins and chylomicrons as regulators of rate of cholesterol synthesis in rat liver in vivo.

An oligosaccharide-containing factor that induces cell differentiation in Dictyostelium discoideum.

Involvement of spectrin in membrane fusion: induction of fusion in human erythrocyte ghosts by proteolytic enzymes and its inhibition by antispectrin antibody.

Regulation of alkaline phosphatase expression in human choriocarcinoma cell lines.

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.

Is the product of the src gene a promoter?

Recognition of differentiation antigens of spermatogenesis in the mouse by using antibodies from spleen cell-myeloma hybrids after syngeneic immunization.

In vitro suppression of UAG and UGA mutants in the thymidine kinase gene of herpes simplex virus.

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.

Rapid turnover of acetyl groups in the four core histones of simian virus 40 minichromosomes.

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

Semisynthetic horse heart [65-homoserine]cytochrome c from three fragments.

Novel protein kinase, AUT-PK 85, isolated from adrenocortical carcinoma: purification and characterization.

Deletion mutants of simian virus 40 defective in biosynthesis of late viral mRNA.

DNA sequencing and melting curve.

Transcription of cloned Xenopus 5S RNA genes by X. laevis RNA polymerase III in reconstituted systems.

Lateral diffusion in binary mixtures of cholesterol and phosphatidylcholines.

Location of the regulatory site for establishment of repression by bacteriophage lambda.

RNA synthesis in isolated nuclei: in vitro initiation of adenovirus 2 major late mRNA precursor.

Caulobacter crescentus nucleoid: analysis of sedimentation behavior and protein composition during the cell cycle.

Sterigmatocystin-DNA interactions: identification of a major adduct formed after metabolic activation in vitro.

Conformations of twisted parallel beta-sheets and the origin of chirality in protein structures.

Helical repeat of DNA in solution.

Resolution of adenylate cyclase sensitive and insensitive to Ca2+ and calcium-dependent regulatory protein (CDR) by CDR-sepharose affinity chromatography.

Biosynthesis and self-assembly of protein S, a development-specific protein of Myxococcus xanthus

Partial primary structure of bacteriorhodopsin: sequencing methods for membrane proteins.

Coupled enzyme systems in a vesicular membrane: oxidative phosphorylation as an example.

Steroid diamine-nucleic acid interactions: partial insertion of dipyrandium between unstacked base pairs of the poly(dA-dT) duplex in solution.

Isolation of a 7S particle from Xenopus laevis oocytes: a 5S RNA-protein complex.

Differences in intracellular distribution of plasminogen activator in growing, confluent, and transformed 3T3 cells.

Conformational properties of the acetylcholine receptor as revealed by studies with constrained depolarizing ligands.

Quaternary enhancement in binding of oxygen by human hemoglobin.

Reconstitution of membranes and embryonic development in dissociated blastula cells of the sea urchin by reinsertion of aggregation-promoting membrane proteins extracted with butanol.

Photobilirubin: an early bilirubin photoproduct detected by absorbance difference spectroscopy.

Self-assembly of microtubules in extracts of cultured HeLa cells and the identification of HeLa microtubule-associated proteins.

mRNA-directed biosynthesis of alpha subunit of thyrotropin: translation in cell-free and whole-cell systems.

Interaction of wild-type and variant mouse 3T3 cells with lectins from Bandeiraea simplicifolia seeds.

Procollagen segment-long-spacing crystallites: their role in collagen fibrillogenesis.

Conservative segregation of parental histones during replication in the presence of cycloheximide.

Resonance Raman studies of bathorhodopsin: evidence for a protonated Schiff base linkage.

High affinity binding of chylomicron remnants to rat liver plasma membranes.

Glycoprotein, elastin, and collagen secretion by rat smooth muscle cells.

Relationship between RNA content and progression of lymphocytes through S phase of cell cycle.

Monoclonal antibodies reacting with murine teratocarcinoma cells.

Evolutionary change in 5S RNA secondary structure and a phylogenic tree of 54 5S RNA species.

Genetic translocation in Staphylococcus aureus.

Genetic control of cobalamin binding in normal and mutant cells: assignment of the gene for 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase to human chromosome 1.

Emetine resistance in Chinese hamster cells is linked genetically with an altered 40S ribosomal subunit protein, S20.

Evolutionary effects of contagious and familial transmission.

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.

Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.

Another approach to in vivo estimation of genetic damage in humans.

Incorporation of glucocerebrosidase into Gaucher's disease monocytes in vitro.

Modification of the blood-brain barrier: increased concentration and fate of enzymes entering the brain.

Metal-binding and detoxification effect of synthetic oligopeptides containing three cysteinyl residues.

Humoral factor that specifically regulates prothrombin (factor II) levels (coagulopoietin-II).

Utilization of trimethylamine and other N-methyl compounds for growth and methane formation by Methanosarcina barkeri.

Distribution of binding sites for 125I-labeled alpha-bungarotoxin in normal and deafferented antennal lobes of Manduca sexta.

Complementary carrier peptide synthesis: general strategy and implications for prebiotic origin of peptide synthesis.

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

Prolyl-leucyl-glycinamide, cyclo(leucylglycine), and derivatives block development of physical dependence on morphine in mice.

Cholecystokinin octapeptide-like immunoreactivity: histochemical localization in rat brain.

Tetraethylammonium: voltage-dependent action on endplate conductance and inhibition of ligand binding to postsynaptic proteins.

Mouse mammary epithelial cells on floating collagen gels: Transepithelial ion transport and effects of prolactin

Subnanosecond motions of tryptophan residues in proteins.

Chicken lysozyme gene contains several intervening sequences.

Identification of the polypeptide chains in Torpedo californica electroplax membranes that interact with a local anesthetic analog.

Competitive inhibition of colchicine binding to tubulin by microtubule-associated proteins.

Evidence for tetradecanal as the natural aldehyde in bacterial bioluminescence.

Interaction of peanut agglutinin with normal human lymphocytes and with leukemic cells.

Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice

Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis.

Mechanochemical properties of brain clathrin: interactions with actin and alpha-actinin and polymerization into basketlike structures or filaments.

Formation and properties of 1000-A-diameter, single-bilayer phospholipid vesicles.

X-ray diffraction studies of fibers and crystals of deoxygenated sickle cell hemoglobin.

Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase.

beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.

Photomutagenesis by chlorinated phenothiazine tranquilizers.

Appearance of catecholamine-synthesizing enzymes during development of rat sympathetic nervous system: possible role of tissue environment.

ATP-dependent renaturation of DNA catalyzed by the recA protein of Escherichia coli.

Interaction of Escherichia coli RNA polymerase with promoters of several coliphage and plasmid DNAs.

Translational and post-translational cleavage of M13 procoat protein: extracts of both the cytoplasmic and outer membranes of Escherichia coli contain leader peptidase activity.

Kinetics of initiation of bacterial protein synthesis.

Identification of a methyl-accepting chemotaxis protein for the ribose and galactose chemoreceptors of Escherichia coli.

Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli.

Phase variation in Salmonella: genetic analysis of a recombinational switch.

Yeast ribosomal DNA genes are located on chromosome XII.

Transplantation of cultured bovine corneal endothelial cells to rabbit cornea: clinical implications for human studies.

Thermosensory transduction in Escherichia coli: inhibition of the thermoresponse by L-serine.

Expression in Escherichia coli of chemically synthesized genes for human insulin.

Fetal phenotypic expression by adult rat hepatocytes on collagen gel/nylon meshes.

Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors.

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Low and high density lipoproteins and chylomicrons as regulators of rate of cholesterol synthesis in rat liver in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Turley, S. D. Dietschy, J. M. Andersen, J. M.
Abstract	The steady-state levels of plasma cholesterol carried in high and low density lipoproteins and in chylomicrons were varied over a wide range by use of a constant-infusion technique. After 40 hr, the rates of hepatic cholesterol synthesis and levels of hepatic cholesterol esters were measured and were related to the plasma level of each of the lipoprotein fractions. From the rates of infusion and the steady-state plasma levels attained, the whole animal clearance rates for cholesterol carried in low density and high density lipoproteins and in chylomicrons were calculated to be 0.53, 0.61, and 42.6 ml/hr, respectively. Hepatic cholesterol ester content increased by 0.8 mug/g for each 1.0 mg/dl increase in the steady-state level of plasma low density lipoprotein cholesterol and by 1.4 mug/g for a similar elevation in plasma high density lipoprotein cholesterol. In contrast, the increase in ester content was 300-fold greater when chylomicrons were infused (330 mug/g). The rate of hepatic cholesterol synthesis was inhibited by a factor of 0.004 and 0.007, respectively, per 1.0 mg/dl increase in the steady-state level of plasma cholesterol carried in either low density or high density lipoprotein but the inhibition was by a factor of 0.255, 50-fold greater, when chylomicrons were infused. Thus, in the steady state, cholesterol carried in either low density or high density lipoproteins is apparently taken up by the liver and regulates the rate of hepatic cholesterol synthesis; however, cholesterol carried in chylomicrons is at least 50-fold more effective in this regard. This marked difference can be attributed to the much higher rates of transport of chylomicron cholesterol into the hepatocyte than of cholesterol carried in either low density or high density plasma lipoproteins.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cholesterol Biosynthesis Chylomicrons Physiology Lipoproteins, HDL Lipoproteins, LDL Liver Metabolism Animals Blood Cholesterol Esters Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in