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Role of pain in placebo analgesia.

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Role of pain in placebo analgesia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bornstein, J. C. Fields, H. L. Levine, J. D. Gordon, N. C.
Abstract	The hypothesis that perceived pain intensity can influence placebo analgesia was tested. One hundred and seven subjects rated their pain from from 0 to 10 on a visual analog scale after a standard wisdom tooth extraction. The expected course of such postoperative pain in the absence of therapy or placebo is a steady increase; this was confirmed by blind administration of the placebo. When placebos were given intravenously in view of the patients, some (placebo nonresponders) reported that their pain increased, whereas others (placebo responders) reported that their pain either decreased or remained the same over the next 60 min. A placebo response was more likely to occur if the pain rating 5 min prior to placebo administration (initial pain) was greater than 2.6. Furthermore, placebo responders with initial pain above this 2.6 level reported significantly greater mean analgesia than those with lower initial pain. Indeed, responders with initial pain less than 2.6 reported no change in pain during the 60 min after administration of a placebo. When their initial pain level was greater than 2.6, they reported a steady decline in pain over this period. However, above the 2.6 level there was no obvious relationship between the magnitude of the placebo analgesia and the initial pain.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Analgesia Pain Drug Therapy Placebos Therapeutic Use Injections, Intravenous Molar Surgery Physiopathology Pain, Postoperative Sensory Thresholds Tooth Extraction Tooth, Impacted Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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