NDLI: Effective tumor immunization induced by cells of elevated membrane-lipid microviscosity.

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Effective tumor immunization induced by cells of elevated membrane-lipid microviscosity.

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Effective tumor immunization induced by cells of elevated membrane-lipid microviscosity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shinitzky, M. Haran-ghera, N. Skornick, Y.
Abstract	The immunogenicity of a series of mouse tumor lines propagated in vivo (T and B lymphomas and mammary adenocarcinoma) was tested after alteration of the cell membrane-lipid microviscosity. Tumor cells used for immunization were first treated to alter the lipid content, then irradiated and injected intraperitoneally into syngeneic mice. A second identical immunization was performed 14 days later. The degree of immunization in the treated mice was assessed by survival time after challenge with untreated viable tumor cells of the same origin as the immunizing cells. For all tumors tested, enrichment of the immunizing cells with cholesterol or cholesteryl hemisuccinate, which increased the membrane-lipid microviscosity significantly, afforded a marked increase in immunization, compared to that obtained with cells that were only irradiated. Furthermore, in over 90% of the mice that were pretreated with cholesteryl hemisuccinate-enriched cells, tumor growth after the challenge was not detectable. Because the lipid-modifying treatments of the immunizing cells involve no toxic substances, these results may provide the basis for a potent approach to immunotherapy of human cancer.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Neoplasm Lymphoma Immunology Mammary Neoplasms, Experimental Membrane Lipids 9,10-Dimethyl-1,2-benzanthracene Animals B-Lymphocytes Membrane Fluidity Mice Mice, Inbred C3H Mice, Inbred C57BL Neoplasm Transplantation Neoplasms, Experimental T-Lymphocytes Transplantation, Isogeneic Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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