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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Seglen, P. O. Gordon, P. B. |
| Abstract | 3-Methyladenine (5 mM) inhibits endogenous protein degradation in isolated rat hepatocytes by about 60%, while having no adverse effect on the degradation of an exogenous protein (asialofetuin), on protein synthesis, or on intracellular ATP levels. 3-Methyladenine appears to act specifically upon the autophagic/lysosomal pathway of degradation, as judged from its lack of effect in the presence of amino acids or a lysosomotropic amine (propylamine). The effect of the purine is not mediated by amino acids because the inhibition of protein degradation is accompanied by a significant depression of intracellular amino acid levels. The ability of 3-methyladenine to suppress the formation of electron microscopically visible autophagosomes suggests that it may be regarded as a specific inhibitor of autophagy. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 79 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1982-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adenine Analogs & Derivatives Liver Metabolism Lysosomes Drug Effects Proteins Pharmacology Adenosine Triphosphate Amino Acids Animals Autolysis Physiopathology Cells, Cultured Cytology Phagocytosis Protein Biosynthesis Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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