NDLI: Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1982 Volume: 79 Issue: 24

Year: 1982 Volume: 79 Issue: 23

Year: 1982 Volume: 79 Issue: 22

Year: 1982 Volume: 79 Issue: 21

Year: 1982 Volume: 79 Issue: 20

Year: 1982 Volume: 79 Issue: 19

Year: 1982 Volume: 79 Issue: 18

Year: 1982 Volume: 79 Issue: 17

Year: 1982 Volume: 79 Issue: 16

Year: 1982 Volume: 79 Issue: 15

Year: 1982 Volume: 79 Issue: 14

Year: 1982 Volume: 79 Issue: 13

Year: 1982 Volume: 79 Issue: 12

Year: 1982 Volume: 79 Issue: 11

Post-translational modification of neuronal proteins: evidence for transglutaminase activity in R2, the giant cholinergic neuron of Aplysia.

Immunocytochemical localization of gamma-glutamyltransferase in rat kidney with protein A-horseradish peroxidase.

Temperature-sensitive copy number mutants of CoIE1 are located in an untranslated region of the plasmid genome.

Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.

Cell-free translation of a biologically active, antigen-specific suppressor T cell factor.

Monoclonal antibody specific for myelin glycoprotein P0: derivation and characterization.

Human papilloma viral DNA replicates as a stable episome in cultured epidermal keratinocytes.

Functional exchange of components between light-activated photoreceptor phosphodiesterase and hormone-activated adenylate cyclase systems.

Stimulation of cyclic AMP accumulation and corticotropin release by synthetic ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action.

Bacteriophage lambda DNA packaging: scanning for the terminal cohesive end site during packaging.

Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites.

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

Use of restriction endonucleases for mapping the allele for beta s-globin.

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

Functional reconstitution of the purified sodium channel protein from rat sarcolemma.

[3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonists and antagonists.

Prediction of the three-dimensional structure of the leader sequence of pre-kappa light chain, a hexadecapeptide.

Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.

Methylation of elongation factor 1 alpha from the fungus Mucor.

Evidence for a role of calmodulin in serum stimulation of Na+ influx in human fibroblasts.

Three Drosophila mutations that block associative learning also affect habituation and sensitization.

P1 site-specific recombination: nucleotide sequence of the recombining sites.

Trimeric intermediate in the in vivo folding and subunit assembly of the tail spike endorhamnosidase of bacteriophage P22.

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus.

Heteropolymer filaments of vimentin and desmin in vascular smooth muscle tissue and cultured baby hamster kidney cells demonstrated by chemical crosslinking.

Binding to selected regions of reovirus mRNAs by a nonstructural reovirus protein.

Possible role of ceramide in defining structure and function of membrane glycolipids.

Subcellular localization of myosin light chain kinase in skeletal, cardiac, and smooth muscles.

Diverse forms of stress lead to new patterns of gene expression through a common and essential metabolic pathway.

Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II).

Changes in the activity and properties of trehalase during early germination of yeast ascospores: correlation with trehalose breakdown as studied by in vivo 13C NMR.

Use of un-derivatized thyroid hormones for photoaffinity labeling of binding proteins.

Molecular motion of DNA as measured by triplet anisotropy decay.

NMR chemical shift imaging in three dimensions.

Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF).

In vitro stimulation of phosphate uptake in isolated chick renal cells by 1,25-dihydroxycholecalciferol.

Decreased intestinal calcium absorption in vivo and normal brush border membrane vesicle calcium uptake in cortisol-treated chickens: evidence for dissociation of calcium absorption from brush border vesicle uptake.

Origin of evolutionary novelty in proteins: how a high-cysteine chorion protein has evolved.

Intracellular potassium: 40K as a primordial gene irradiator.

Tissue specificity and clustering of methylated cystosines in bovine satellite I DNA.

Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia.

Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia.

Replication and expression of a bacterial--mitochondrial hybrid plasmid in the fungus Podospora anserina.

Long axons within the striate cortex: their distribution, orientation, and patterns of connection.

Specificity and localization of the acetylcholine receptor kinase.

gamma-Aminobutyric acid antagonists decrease junctional communication between L-horizontal cells of the retina.

Murine T cell-specific Ia antigens: monoclonal antibodies define an I-A-encoded T lymphocyte structure.

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

Long-term culture of B lymphocytes and their precursors from murine bone marrow.

Specific recognition of the product of a transferred major histocompatibility complex gene by cytotoxic T lymphocytes.

Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis.

Protein complexes from active replicative fractions associate in vitro with the replication origins of yeast 2-micrometers DNA plasmid.

Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.

Geometric specificity of alcohol dehydrogenases and its potential for separation of trans and cis isomers of unsaturated aldehydes.

Synthesis and biological activity of a profluorescent analogue of coenzyme B12.

Construction of a yeast actin gene intron deletion mutant that is defective in splicing and leads to the accumulation of precursor RNA in transformed yeast cells.

Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.

Nucleotide sequence of the SUF2 frameshift suppressor gene of Saccharomyces cerevisiae.

Year: 1982 Volume: 79 Issue: 10

Year: 1982 Volume: 79 Issue: 9

Year: 1982 Volume: 79 Issue: 8

Year: 1982 Volume: 79 Issue: 7

Year: 1982 Volume: 79 Issue: 6

Year: 1982 Volume: 79 Issue: 5

Year: 1982 Volume: 79 Issue: 4

Year: 1982 Volume: 79 Issue: 3

Year: 1982 Volume: 79 Issue: 2

Year: 1982 Volume: 79 Issue: 1

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oliver, D. B. Benjamin, T. L. Carmichael, G. G. Dorsky, D. I. Schaffhausen, B. S.
Abstract	We have constructed a transformation-defective polyoma virus mutant (Py 1387-T) that directs the synthesis of a normal small tumor antigen, a functional large tumor antigen, and a truncated (51,000-dalton) middle-sized tumor (mT) antigen that lacks 37 amino acids at its COOH terminus. The shortened mT polypeptide is missing the hydrophobic 'tail' thought to be responsible for the anchorage of this protein into the plasma membrane and is in fact in cytosol fractions. This truncated mT polypeptide is inactive in an in vitro protein kinase assay and is altered in its phosphorylation in vivo. Mutant 1387-T differs from wild-type virus in having a T.A base pair instead of a C.G base at nucleotide position 1387. This change was introduced into viral DNA by using a synthetic undecanucleotide as a specific mutagen. Wild-type polyoma DNA was rendered single stranded by molecular cloning into coliphage M13. The oligonucleotide, which hybridizes with a mismatch at the site to be altered, was used to prime the synthesis of double-stranded closed circular DNA. Progeny recombinant phage were screened by DNA sequence analysis for the desired base change. The polyoma mutant was reconstructed from recombinant phage replicative form DNA molecules containing the mutation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	79
Language	English
Publisher	National Academy of Sciences
Publisher Date	1982-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Viral Physiology Cell Transformation, Viral Polyomavirus Protein Kinases Metabolism Animals Antigens, Viral, Tumor Cell Membrane Cells, Cultured Cytoplasm DNA, Recombinant Mice Mutation Phosphotyrosine Immunology Structure-Activity Relationship Tyrosine Analogs & Derivatives Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in