NDLI: Difference in saturable binding of low density lipoprotein to liver membranes from normocholesterolemic subjects and patients with heterozygous familial hypercholesterolemia.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1982 Volume: 79 Issue: 24

Year: 1982 Volume: 79 Issue: 23

Year: 1982 Volume: 79 Issue: 22

Year: 1982 Volume: 79 Issue: 21

Year: 1982 Volume: 79 Issue: 20

Expression of transferred thymidine kinase genes is controlled by methylation.

Control of ColE1 DNA replication: the rop gene product negatively affects transcription from the replication primer promoter.

Extracts from the brains of hibernating and alert ground squirrels: effects on cells in culture.

Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

Steady state of an ATP-driven calcium pump: limitations on kinetic and thermodynamic parameters.

Transcription terminates at lambda tR1 in three clusters.

Initiation of bacteriophage lambda DNA replication in vitro with purified lambda replication proteins.

Distance from cohesive end site cos determines the replication requirement for recombination in phage lambda.

Nucleotide sequence of the ilvB promoter-regulatory region: a biosynthetic operon controlled by attenuation and cyclic AMP.

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.

Corticotropin-releasing factor stimulates phospholipid methylation and corticotropin secretion in mouse pituitary tumor cells.

IgA interaction with the asialoglycoprotein receptor.

In vitro assembly of the nonglycosylated membrane protein (M) of Sendai virus.

Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells.

Difference in saturable binding of low density lipoprotein to liver membranes from normocholesterolemic subjects and patients with heterozygous familial hypercholesterolemia.

Energy-dependent arsenate efflux: the mechanism of plasmid-mediated resistance.

Energetics of plasmid-mediated arsenate resistance in Escherichia coli.

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

Yeast invertase polymorphism is correlated with variable states of oligosaccharide chain phosphorylation.

Specific interactions of Saccharomyces cerevisiae proteins with a promoter region of eukaryotic tRNA genes.

Intracellular K+ and the mitogenic response of 3T3 cells to peptide factors in serum-free medium.

Internal structure of a mitochondrial intron of Aspergillus nidulans.

Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons.

Recovery from prolonged abnormalities of canine myocardium salvaged from ischemic necrosis by coronary reperfusion. : Correction.

Heat shock and recovery are mediated by different translational mechanisms.

Opal suppressor serine tRNAs from bovine liver form phosphoseryl-tRNA.

Evidence that a reducible xylosyl-lysine is the protein linkage of dermatan sulfate.

Thyrotropin-releasing hormone mobilizes Ca2+ from endoplasmic reticulum and mitochondria of GH3 pituitary cells: characterization of cellular Ca2+ pools by a method based on digitonin permeabilization.

cDNA clone for the heavy chain of the human B cell alloantigen DC1: strong sequence homology to the HLA-DR heavy chain.

Normal coordinate analysis of the copper center of azurin and the assignment of its resonance Raman spectrum.

Left-handed helices for DNA: studies on poly[d(I-C)].

Mouse EcoRI satellite DNA contains a sequence homologous to the long terminal repeat of the intracisternal A particle gene.

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

Priming of reovirus transcription by GppppG and formation of CpG(5')GpC.

A bent monomeric conformation of myosin from smooth muscle.

Amino acid sequence homology among the 2-hydroxy acid dehydrogenases: mitochondrial and cytoplasmic malate dehydrogenases form a homologous system with lactate dehydrogenase.

Relationship between the total size of exons and introns in protein-coding genes of higher eukaryotes.

Bioassay for components regulating eukaryotic gene expression: a chromosomal factor involved in the generation of histone mRNA 3' termini.

Structural studies of isolated native thick filaments from rabbit psoas muscle with AMP deaminase decoration.

Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA.

Expression of the alpha subunit of human chorionic gonadotropin is specifically correlated with tumorigenic expression in human cell hybrids.

Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.

Identification of a third rhodopsin-like pigment in phototactic Halobacterium halobium.

X-ray absorption spectroscopy of the dimeric iron site in azidomethemerythrin from Phascolopsis gouldii.

Tissue-specific and species-specific monoclonal antibodies to avian red cell nuclear proteins.

Identification of a pterin as the acrasin of the cellular slime mold Dictyostelium lacteum.

Fibrinogen and its fragment D stimulate proliferation of human hemopoietic cells in vitro.

Developmentally regulated interconversions between end product-inhibitable and noninhibitable forms of a first pathway-specific enzyme activity can be mimicked in vitro by protein dephosphorylation-phosphorylation reactions.

Identification of human genomic clones coding the major histocompatibility antigens HLA-a2 and HLA-B7 by DNA-mediated gene transfer.

Identification of the 45-base-long primordial building block of the entire class I major histocompatibility complex antigen gene.

Amino acid sequence homologies and glycosylation differences between the fourth component of murine complement and sex-limited protein.

Synthesis of beta-hexosaminidase in cell-free translation and in intact fibroblasts: an insoluble precursor alpha chain in a rare form of Tay-Sachs disease.

Human noninsulin-dependent diabetes: identification of a defect in plasma cholesterol transport normalized in vivo by insulin and in vitro by selective immunoadsorption of apolipoprotein E.

Possible mechanism for donor DNA binding and transport in Haemophilus.

A neural cell adhesion molecule from human brain.

Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver.

Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.

Year: 1982 Volume: 79 Issue: 19

Year: 1982 Volume: 79 Issue: 18

Year: 1982 Volume: 79 Issue: 17

Year: 1982 Volume: 79 Issue: 16

Year: 1982 Volume: 79 Issue: 15

Year: 1982 Volume: 79 Issue: 14

Year: 1982 Volume: 79 Issue: 13

Year: 1982 Volume: 79 Issue: 12

Year: 1982 Volume: 79 Issue: 11

Year: 1982 Volume: 79 Issue: 10

Year: 1982 Volume: 79 Issue: 9

Year: 1982 Volume: 79 Issue: 8

Year: 1982 Volume: 79 Issue: 7

Year: 1982 Volume: 79 Issue: 6

Year: 1982 Volume: 79 Issue: 5

Year: 1982 Volume: 79 Issue: 4

Year: 1982 Volume: 79 Issue: 3

Year: 1982 Volume: 79 Issue: 2

Year: 1982 Volume: 79 Issue: 1

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Difference in saturable binding of low density lipoprotein to liver membranes from normocholesterolemic subjects and patients with heterozygous familial hypercholesterolemia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Harders-spengel, K. Wood, C. B. Thompson, G. R. Myant, N. B. Soutar, A. K.
Abstract	To investigate the possible role of the low density lipoprotein (LDL) receptor in the catabolism of LDL by the human liver, the binding of 125I-labeled LDL to membrane fractions prepared from human liver biopsies was determined. Biopsy samples taken for routine histology were obtained from seven patients with heterozygous familial hypercholesterolemia, one with non-familial hypercholesterolemia, and seven normocholesterolemic subjects. LDL was bound by the membranes from normal subjects in a saturable manner that was inhibited by 56% in the presence of excess LDL. Binding of LDL was also inhibited by modification of the lipoproteins with 1,2-cyclohexanedione. The amount of 125I-labeled LDL bound to membranes from familial hypercholesterolemic livers that could be displaced with excess LDL was significantly less than that bound by normocholesterolemic membranes. These observations suggest that LDL receptors are expressed in normal human liver and are defective in the livers of familial hypercholesterolemic patients.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	79
Language	English
Publisher	National Academy of Sciences
Publisher Date	1982-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hyperlipoproteinemia Type II Metabolism Lipoproteins, LDL Liver Receptors, Cell Surface Cell Membrane Hydrogen-Ion Concentration Kinetics Osmolar Concentration Receptors, LDL Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in