NDLI: Regulation of the pro-opiomelanocortin mRNA levels in rat pituitary by dopaminergic compounds.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1983 Volume: 80 Issue: 24

Year: 1983 Volume: 80 Issue: 23

Year: 1983 Volume: 80 Issue: 22

Year: 1983 Volume: 80 Issue: 21

Year: 1983 Volume: 80 Issue: 20

Year: 1983 Volume: 80 Issue: 19

Year: 1983 Volume: 80 Issue: 18

Year: 1983 Volume: 80 Issue: 17

Year: 1983 Volume: 80 Issue: 16

Year: 1983 Volume: 80 Issue: 15

Year: 1983 Volume: 80 Issue: 14

Year: 1983 Volume: 80 Issue: 13

Year: 1983 Volume: 80 Issue: 12

Year: 1983 Volume: 80 Issue: 11

Year: 1983 Volume: 80 Issue: 10

Year: 1983 Volume: 80 Issue: 9

Year: 1983 Volume: 80 Issue: 8

Evidence for the involvement of a cyclic AMP-independent protein kinase in the activation of soluble tyrosine hydroxylase from rat striatum.

Retrograde transport of gamma-amino[3H]butyric acid reveals specific interlaminar connections in the striate cortex of monkey.

Cholecystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels.

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

Linkage of beta 2-microglobulin and ly-m11 by molecular cloning and DNA-mediated gene transfer.

Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.

Nucleotide sequence of the human parathyroid hormone gene.

Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.

Arachidonic acid deficiency in streptozotocin-induced diabetes.

Photoaffinity label for the alpha 1-adrenergic receptor: synthesis and effects on membrane and affinity-purified receptors.

Isolation of cellular DNA sequences that allow expression of adjacent genes.

Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc.

Evidence for phosphorylation/dephosphorylation of rat liver acyl-CoA:cholesterol acyltransferase.

Loss of cholesterol 7 alpha-hydroxylase activity in vitro in the presence of bivalent metal ions and by dialysis of rat liver microsomes.

Flow dichroism evidence for tilting of the bases when DNA is in solution.

High-frequency spontaneous mutation in the bacterio-opsin gene in Halobacterium halobium is mediated by transposable elements.

Voltage-gated Ca2+ channel in mouse myeloma cells.

Structural and functional evidence for multiple channel complexes in the outer membrane of Neurospora crassa mitochondria.

pH and the recycling of transferrin during receptor-mediated endocytosis.

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

Down-regulation of epidermal growth factor receptor correlates with plasminogen activator activity in human A431 epidermoid carcinoma cells.

Nuclear ribonucleoprotein release and nucleoside triphosphatase activity are inhibited by antibodies directed against one nuclear matrix glycoprotein.

Flow of mitochondrial DNA across a species boundary.

Genetic transposition and insertional mutagenesis in Bacillus subtilis with Streptococcus faecalis transposon Tn917.

Activation of Chi, a recombinator, by the action of an endonuclease at a distant site.

Recombination involving transposable elements: role of target molecule replication in Tn1 delta Ap-mediated replicon fusion.

Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments.

Dihydropyridine receptor in rat brain labeled with [3H]nimodipine.

High incidence of human type-C retrovirus (HTLV) in family members of a HTLV-positive Japanese T-cell leukemia patient.

Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP.

A proteolytic artifact associated with the lysis of bacteria by egg white lysozyme.

Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding.

Mutator strains of Escherichia coli, mutD and dnaQ, with defective exonucleolytic editing by DNA polymerase III holoenzyme.

Transcription termination in vitro at the tryptophan operon attenuator is controlled by secondary structures in the leader transcript.

Structure and coding properties of a dominant Escherichia coli mutator gene, mutD.

Organization of actin cytoskeleton in normal and regenerating arterial endothelial cells.

Component A of the methyl coenzyme M methylreductase system of Methanobacterium: resolution into four components.

Isolation of an intact DNA polymerase-primase from embryos of Drosophila melanogaster.

Evidence for a multiple random coupling mechanism in the alpha-ketoglutarate dehydrogenase multienzyme complex of Escherichia coli: a computer model analysis.

Mapping of the genes encoding the HLA-DR alpha chain and the HLA-related antigens to a chromosome 6 deletion by using genomic blotting.

Recurrence of 49-base decamers, nonomers, and octamers within mouse C mu gene of Ig heavy chain and its primordial building block.

Chemical evidence that catecholamines are transported across the chromaffin granule membrane as noncationic species.

Three human transforming genes are related to the viral ras oncogenes.

Cloning of cDNA encoding the pre-beta subunit of mouse thyrotropin.

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

Cooperative model for the binding of Xenopus transcription factor A to the 5S RNA gene.

Genes for catecholamine biosynthesis: cloning by expression and identification of the cDNA for rat dopamine beta-hydroxylase.

Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids.

Sequence dependence of hydrogen exchange kinetics in DNA duplexes at the individual base pair level in solution.

Cloning and sequence analysis of cDNA for rat angiotensinogen.

Regulation of the pro-opiomelanocortin mRNA levels in rat pituitary by dopaminergic compounds.

Total synthesis of insulin-like growth factor I (somatomedin C).

Nanosecond absorption spectroscopy of hemoglobin: elementary processes in kinetic cooperativity.

Immunospecific vesicle targeting facilitates microinjection into lymphocytes.

Decreased de novo synthesis of glomerular proteoglycans in diabetes: biochemical and autoradiographic evidence.

Erythroleukemia cells: variants inducible for hemoglobin synthesis without commitment to terminal cell division.

'Silent' nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

Cultured hepatocytes from mouse strains expressing high and low levels of the fourth component of complement differ in rate of synthesis of the protein.

Autologous and allogeneic typing of human leukemia cells: definition of surface antigens restricted to lymphocytic leukemia cells.

Prothrombinase complex assembly on the platelet surface is mediated through the 74,000-dalton component of factor Va.

Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain.

C3d receptors are expressed on human monocytes after in vitro cultivation.

Year: 1983 Volume: 80 Issue: 7

Year: 1983 Volume: 80 Issue: 6

Year: 1983 Volume: 80 Issue: 5

Year: 1983 Volume: 80 Issue: 4

Year: 1983 Volume: 80 Issue: 3

Year: 1983 Volume: 80 Issue: 2

Year: 1983 Volume: 80 Issue: 1

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Regulation of the pro-opiomelanocortin mRNA levels in rat pituitary by dopaminergic compounds.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roberts, J. L. Chen, C. L. Dionne, F. T.
Abstract	Dopamine-containing neurons directly innervate the intermediate lobe of the pituitary and dopaminergic compounds exert inhibitory effects on the secretion and the content of alpha-melanocyte-stimulating hormone and beta-endorphin in this tissue. In this study, we have investigated the effects of dopamine receptor agonists and antagonists on the level of pro-opiomelanocortin (POMC) mRNA in rat pituitary. RNAs isolated from neurointermediate pituitary (NIP) or anterior pituitary were spotted on nitrocellulose filters and the levels of POMC mRNA were quantified by hybridization to a POMC-specific complementary DNA probe coupled with autoradiography and densitometry. Administration of a dopamine receptor antagonist, haloperidol (2 mg/kg per day), to adult female rats resulted in a 3- to 5-fold increase in POMC mRNA level in the NIP. Treatment with the dopamine agonist 2-Br-alpha-ergocryptine (1 mg/kg per day) decreased significantly the content of POMC mRNA in the NIP. These drugs had no apparent effect on the POMC mRNA levels in the anterior pituitary. The effect of haloperidol and ergocryptine on POMC mRNA in the NIP is time- and dose-dependent. The elevation of POMC mRNA content in the NIP by haloperidol can be observed as early as 6 hr after treatment. These effects of dopaminergic compounds can also be demonstrated in adult male and ovariectomized female rats. The beta-endorphin content of the NIP, as measured by radioimmunoassay, and the de novo synthesis of POMC, as determined by radioactive amino acid labeling and two-dimensional gel electrophoresis analysis, also show negative regulation by dopaminergic compounds.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	80
Language	English
Publisher	National Academy of Sciences
Publisher Date	1983-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dopamine Pharmacology Gene Expression Regulation Drug Effects Pituitary Gland Physiology Pituitary Hormones, Anterior Genetics Protein Precursors Animals Castration Dose-Response Relationship, Drug Ergolines Haloperidol Pro-Opiomelanocortin RNA, Messenger Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in