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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Weill, J. C. Reynaud, C. A. Dahan, A. |
| Abstract | Recombinant cDNA plasmids have been constructed from chicken spleen poly(A)-containing RNA. Two clones have been selected and provide the sequence determination of a chicken lambda immunoglobulin light chain: they include the complete variable, constant, and 3' untranslated regions of the chicken lambda light chain mRNA and part of the leader sequence. Comparison of the chicken light chain constant region with both human and mouse lambda constant sequences indicates 61% homology at the amino acid level. Unexpectedly, the chicken variable sequence is 53-63% homologous to human variable sequences when it is compared to the various lambda subgroups and only 42% homologous to the mouse V lambda 1 sequence. The degree of homology between the variable regions of these three species does not easily correlate with their phylogenetic relationship. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 80 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1983-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Immunoglobulin Light Chains Genetics Immunoglobulin Lambda-Chains RNA, Messenger Amino Acid Sequence Animals Cloning, Molecular DNA Metabolism Mice Plasmids Protein Biosynthesis Rabbits Reticulocytes Species Specificity Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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