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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ar-rushdi, A. Lenoir, G. Emanuel, B. Finan, J. Nowell, P. C. Erikson, J. Nishikura, K. Croce, C. M. |
| Abstract | We have studied somatic cell hybrids between mouse myeloma and JI Burkitt lymphoma cells carrying a t(2;8) chromosome translocation for the expression of human kappa chains. and for the presence and rearrangements of the human c-myc oncogene and kappa chain genes. Our results indicate that the c-myc oncogene is unrearranged and remains on the 8q+ chromosome of JI cells. Two rearranged C kappa genes were detected: the expressed allele on normal chromosome 2 and the excluded kappa allele that was translocated from chromosome 2 to the involved chromosome 8 (8q+). The distribution of V kappa and C kappa genes in hybrid clones retaining different human chromosomes indicated that C kappa is distal to V kappa on 2p and that the breakpoint in this Burkitt lymphoma is within the region carrying V kappa genes. High levels of transcripts of the c-myc gene were found when it resided on the 8q+ chromosome but not on the normal chromosome 8, demonstrating that translocation of a kappa locus to region distal to the c-myc oncogene enhances c-myc transcription. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 80 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1983-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genes Immunoglobulin Light Chains Genetics Immunoglobulin Kappa-Chains Oncogenes Transcription, Genetic Translocation, Genetic Animals Burkitt Lymphoma Cell Line Clone Cells Cloning, Molecular DNA Hybrid Cells Karyotyping Mice Nucleic Acid Hybridization Plasmacytoma Trisomy Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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