NDLI: Neurotrophic factor for central neurons.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1984 Volume: 81 Issue: 24

Year: 1984 Volume: 81 Issue: 23

Year: 1984 Volume: 81 Issue: 22

Year: 1984 Volume: 81 Issue: 21

Year: 1984 Volume: 81 Issue: 20

Year: 1984 Volume: 81 Issue: 19

Year: 1984 Volume: 81 Issue: 18

Year: 1984 Volume: 81 Issue: 17

Year: 1984 Volume: 81 Issue: 16

Year: 1984 Volume: 81 Issue: 15

Year: 1984 Volume: 81 Issue: 14

Year: 1984 Volume: 81 Issue: 13

Year: 1984 Volume: 81 Issue: 12

Year: 1984 Volume: 81 Issue: 11

Year: 1984 Volume: 81 Issue: 10

Year: 1984 Volume: 81 Issue: 9

Year: 1984 Volume: 81 Issue: 8

Year: 1984 Volume: 81 Issue: 7

Year: 1984 Volume: 81 Issue: 6

Year: 1984 Volume: 81 Issue: 5

Year: 1984 Volume: 81 Issue: 4

Biologic activity in a fragment of recombinant human interferon alpha.

Intermediate filaments in monkey kidney TC7 cells: focal centers and interrelationship with other cytoskeletal systems.

Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection.

Developmental regulation of cytokeratins in cells of the rat mammary gland studied with monoclonal antibodies.

Isolation of cDNA clones for human complement component C2.

IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside.

Two different Na,K-ATPases in the optic nerve: cells of origin and axonal transport.

Isolation and partial renaturation of proteolytic fragments of the myosin head.

Functional molecular weight of the lac carrier protein from Escherichia coli as studied by radiation inactivation analysis.

Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP.

Ca2+-ATPase of the sarcoplasmic reticulum shares a common domain with a membrane glycoprotein associated with the cytoskeleton of microvilli.

Proteolytic activation of a bioactive cardiac peptide by in vitro trypsin cleavage.

Rearranged sequences of a human Kpn I element.

Generation of a Tn5 promoter probe and its use in the study of gene expression in Caulobacter crescentus.

RNase H confers specificity in the dnaA-dependent initiation of replication at the unique origin of the Escherichia coli chromosome in vivo and in vitro.

Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

Structure of a human gastrin gene.

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II.

Molecular analysis of the Neurospora qa-1 regulatory region indicates that two interacting genes control qa gene expression.

The subtilisin E gene of Bacillus subtilis is transcribed from a sigma 37 promoter in vivo.

Reconstitution of neurotoxin-modulated ion transport by the voltage-regulated sodium channel isolated from the electroplax of Electrophorus electricus.

Kindling alters the calcium/calmodulin-dependent phosphorylation of synaptic plasma membrane proteins in rat hippocampus.

Site-specific cleavage of DNA at 8- and 10-base-pair sequences.

Molecular cloning of a unique human T-cell leukemia virus (HTLV-IIMo).

Amino acid sequence homology among the major outer membrane proteins of Escherichia coli.

Insulin stimulation of phospholipid methylation in isolated rat adipocyte plasma membranes.

Tumor cell proteinase visualization and quantification using a fluorescent transition-state analog probe.

Molecular cloning of hormone-responsive genes from the yeast Saccharomyces cerevisiae.

Specificity of polyamine requirements for the replication and maintenance of different double-stranded RNA plasmids in Saccharomyces cerevisiae.

Neurotrophic factor for central neurons.

On the use of sequence homologies to predict protein structure: identical pentapeptides can have completely different conformations.

Hemizygous interstitial deletion of chromosome 15 (band D) in three translocation-negative murine plasmacytomas.

Regional assignment of the structural gene for human alpha-L-iduronidase.

Fibroblasts from patients with hereditary cutaneous malignant melanoma are abnormally sensitive to the mutagenic effect of simulated sunlight and 4-nitroquinoline 1-oxide.

Distinct mechanisms may account for the growth-promoting activity of interleukin 3 on cells of lymphoid and myeloid origin.

Temperature dependence of the resonance Raman spectra of plastocyanin and azurin between cryogenic and ambient conditions.

Prothymosin alpha: isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus.

Evaluation of critical groups required for the binding of heparin to antithrombin.

3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.

Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.

Two initiation sites detected in the small s1 species of reovirus mRNA by dipeptide synthesis in vitro.

A quantitative model for the cooperative mechanism of human hemoglobin.

Denervated skeletal muscle displays discoordinate regulation for the synthesis of several myofibrillar proteins.

Further clues concerning the vectors essential to regulation of hexose transport, as studied in fibroblast cultures from a metabolic mutant.

Glucocorticoid-induced phospholipase A2-inhibitory proteins mediate glucocorticoid teratogenicity in vitro.

beta-Thalassemia in American Blacks: novel mutations in the 'TATA' box and an acceptor splice site.

X chromosome-linked muscular dystrophy (mdx) in the mouse.

Detection of a secreted form of the murine H-2 class I antigen with an antibody against its predicted carboxyl terminus.

Chaotic behavior in dopamine neurodynamics.

Optimal sequential sampling from two populations.

Induction of two genes by glucose starvation in hamster fibroblasts.

Trypanosome variant-specific glycoproteins: a polygene protein family with multiple folding patterns?

Effect of ultraviolet radiation on production of epidermal cell thymocyte-activating factor/interleukin 1 in vivo and in vitro.

Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory cells.

Year: 1984 Volume: 81 Issue: 3

Year: 1984 Volume: 81 Issue: 2

Year: 1984 Volume: 81 Issue: 1

Retinal migration during dark reduction of bacteriorhodopsin.

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Neurotrophic factor for central neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Müller, H. W. Beckh, S. Seifert, W.
Abstract	A serum-free culture of dissociated neurons from embryonic rat hippocampus has been established as a rapid and quantitative in vitro test system for neurotrophic signals in the mammalian brain. By means of this cell culture bioassay, a novel low molecular weight neurotrophic factor (NTF) could be identified. NTF is essential for in vitro brain neuron development, promoting survival and neurite outgrowth. The diffusible factor is synthesized and secreted into serum-free defined medium by cultured astrocytes from rat cerebral hemispheres. The number of viable neurons responding to NTF by neurite outgrowth is dependent on the concentration of the factor. Fractionation of astroglial conditioned medium by gel filtration on columns of Sephadex G-10 recovered biological activity of NTF in a single sharp peak corresponding to an apparent molecular weight of approximately equal to 500. NTF is stable to heat and cold and resistant to trypsin and pronase. Unlike nerve growth factor, NTF has no apparent effect on the neurite outgrowth of peripheral neurons. NTF-like activity is present in situ in the mammalian brain, in certain other nonneural tissues, and in C6 and B12 glioma cell conditioned media.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	81
Language	English
Publisher	National Academy of Sciences
Publisher Date	1984-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Astrocytes Physiology Brain Hippocampus Nerve Tissue Proteins Isolation & Purification Neurons Animals Animals, Newborn Drug Effects Axons Cells, Cultured Fluorescent Antibody Technique Glioma Physiopathology Immune Sera Nerve Growth Factors Pharmacology Tissue Distribution Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in