NDLI: Increased rates of polypeptide chain elongation in placental explants from human diabetics.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1984 Volume: 81 Issue: 24

Year: 1984 Volume: 81 Issue: 23

Year: 1984 Volume: 81 Issue: 22

Year: 1984 Volume: 81 Issue: 21

Year: 1984 Volume: 81 Issue: 20

Year: 1984 Volume: 81 Issue: 19

Year: 1984 Volume: 81 Issue: 18

Year: 1984 Volume: 81 Issue: 17

Year: 1984 Volume: 81 Issue: 16

Year: 1984 Volume: 81 Issue: 15

Year: 1984 Volume: 81 Issue: 14

Year: 1984 Volume: 81 Issue: 13

Year: 1984 Volume: 81 Issue: 12

Year: 1984 Volume: 81 Issue: 11

Year: 1984 Volume: 81 Issue: 10

Year: 1984 Volume: 81 Issue: 9

Year: 1984 Volume: 81 Issue: 8

Year: 1984 Volume: 81 Issue: 7

Year: 1984 Volume: 81 Issue: 6

Year: 1984 Volume: 81 Issue: 5

Isolation and characterization of the rat tyrosine aminotransferase gene.

Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase.

Messenger RNA for an antigen-specific binding molecule from an antigen-specific T-cell hybrid.

Axonal transport of a subclass of tau proteins: evidence for the regional differentiation of microtubules in neurons.

Autodigestion of lexA and phage lambda repressors.

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

Formation of IgE-binding factors by human T-cell hybridomas.

Expression of an immunoglobulin heavy chain gene transfected into lymphocytes.

Increased intracellular concentration of an initiator protein markedly reduces the minimal sequence required for initiation of DNA synthesis.

Analysis of the pleiotropic regulation of flagellar and chemotaxis gene expression in Caulobacter crescentus by using plasmid complementation.

Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region.

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.

Monitoring of cytosolic free Ca2+ in C5a-stimulated neutrophils: loss of receptor-modulated Ca2+ stores and Ca2+ uptake in granule-free cytoplasts.

Assembly in vitro of a spanning membrane protein of the endoplasmic reticulum: the E1 glycoprotein of coronavirus mouse hepatitis virus A59.

Virus-plasmid interactions: mutants of bacteriophage T3 that abortively infect plasmid F-containing (F+) strains of Escherichia coli.

Transformation of Aspergillus nidulans by using a trpC plasmid.

Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA.

In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon.

Molecular cloning of the mouse ouabain-resistance gene.

groEL and dnaK genes of Escherichia coli are induced by UV irradiation and nalidixic acid in an htpR+-dependent fashion.

Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.

kappa gene diversity among the clonal progeny of pre-B lymphocytes.

Comparison of the complete nucleotide sequences of the genomes of the neurovirulent poliovirus P3/Leon/37 and its attenuated Sabin vaccine derivative P3/Leon 12a1b.

Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome.

Interaction of calcium channel blockers with non-neuronal benzodiazepine binding sites.

Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus.

Construction of shuttle vectors capable of conjugative transfer from Escherichia coli to nitrogen-fixing filamentous cyanobacteria.

Autoradiographic localization of angiotensin II receptors in rat brain.

Quantitative autoradiography of beta 1- and beta 2-adrenergic receptors in rat brain.

Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.

Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator.

The free energy of DNA supercoiling is enthalpy-determined.

Post-translational activation introduces a free radical into pyruvate formate-lyase.

Contact points between transcription machinery and the fibroin gene promoter deduced by functional tests of single-base substitution mutants.

Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry.

Selective killing of Fc-receptor-bearing tumor cells through endocytosis of a drug-carrying immune complex.

Mutational specificity of depurination.

beta-Lactamase-catalyzed hydrolysis of acyclic depsipeptides and acyl transfer to specific amino acid acceptors.

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

Characteristics of human lipoproteins isolated by selected-affinity immunosorption of apolipoprotein A-I.

Isolation and partial characterization of concanavalin A receptors on cloned cytotoxic T lymphocytes.

Identification of a sulfate-bearing molecule associated with HLA class II antigens.

Growth hormone-releasing factor regulates growth hormone mRNA in primary cultures of rat pituitary cells.

Regioselective arylation of ribose in adenosine and guanosine with the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.

9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma.

Estradiol feedback effects on the alpha-subunit mRNA in the sheep pituitary gland: correlation with serum and pituitary luteinizing hormone concentrations.

Increased rates of polypeptide chain elongation in placental explants from human diabetics.

Plasma membrane biogenesis in eukaryotic cells: translocation of newly synthesized lipid.

Distribution of prothymosin alpha in rat tissues.

The effects of water-soluble solutes on the phase transitions of phospholipids.

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

Time and voltage windows for reversing the electrical block to fertilization.

Mouse yolk sac and intraembryonic tissues produce factors able to elicit differentiation of erythroid burst-forming units and colony-forming units, respectively.

Cell adhesion and morphogenesis: the regulator hypothesis.

Human dihydrofolate reductase gene is located in chromosome 5 and is unlinked to the related pseudogenes.

Segregation of on- and off-center afferents in mink visual cortex.

Diffusion and binding constants for acetylcholine derived from the falling phase of miniature endplate currents.

Cultural and biological evolutionary processes: gene-culture disequilibrium.

Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex.

Artifacts caused by cell microinjection.

Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia.

Year: 1984 Volume: 81 Issue: 4

Year: 1984 Volume: 81 Issue: 3

Year: 1984 Volume: 81 Issue: 2

Year: 1984 Volume: 81 Issue: 1

Retinal migration during dark reduction of bacteriorhodopsin.

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Increased rates of polypeptide chain elongation in placental explants from human diabetics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Folman, R. Pierce, D. R. Gyves, M. T. Hochberg, A. A. Ilan, J.
Abstract	Average rates of polypeptide chain elongation were determined in placental explants of first trimester and term placentas from both normal and diabetic human pregnancies. Average ribosome half-transit times were determined by measuring the kinetics of transfer of labeled polypeptides from polysomal-bound to released polypeptides. The average half-transit time decreases from 75 sec per ribosome in first trimester explants to 56 sec per ribosome in term placentas. The average polypeptide molecular weights synthesized by explants from first trimester and in term are 49,300 and 49,600, respectively, which are not significantly different. The average elongation rates for first trimester and term placental explants are 172 and 231 amino acids per minute per ribosome, respectively, which are significantly different. Moreover, the average polypeptide molecular weight synthesized by term placentas from diabetic pregnancies is 48,200, while the average ribosome half-transit time is 40 sec. Thus, ribosomes from explants of term placenta from diabetics move along the average message at a much higher speed than do ribosomes in normal term tissue. The assembly rate of amino acid into polypeptide in explant of placenta of diabetic mothers is 314 amino acids per minute, which is significantly faster than 231 amino acids per minute in normal term tissue. These findings indicate that during placental development and in diabetic pregnancy there is a large change in the actual rates at which amino acids are added to the nascent polypeptide chain--i.e., the rates in polypeptide chain elongation. Therefore, translation-level regulation of protein synthesis in placenta plays a significant part in the magnitude of the response to developmental and other physiological stimulations.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	81
Language	English
Publisher	National Academy of Sciences
Publisher Date	1984-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Peptide Chain Elongation, Translational Placenta Metabolism Pregnancy In Diabetics Chorion Kinetics Molecular Weight Organ Culture Techniques Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Third Ribosomes Sulfur Radioisotopes Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in