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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Patterson, M. Walker, W. H. Chung, S. W. Chui, D. H. Wong, S. C. Clarke, B. J. |
| Abstract | Human embryonic zeta-globin chains are alpha-globin-like chains that are normally present during the first three months of gestation. In this investigation, zeta-globin chains measured by a specific and sensitive radioimmunoassay and by an electrophoretic technique were found to be present in all 7 patients studied with hereditary Hb H disease, and in 8 out of 24 patients with alpha-thalassemia trait. zeta-Globin chains were not detected in 20 other patients with beta-thalassemia trait. These results suggest that the deletion of two alpha-globin genes on the same chromosome is accompanied by the continued expression of embryonic zeta-globin genes in adult individuals. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 81 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1984-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Globins Thalassemia Blood Adolescent Child, Preschool Electrophoresis, Polyacrylamide Gel Embryo, Mammalian Isolation & Purification Hemoglobins Hemolysis Infant Pregnancy Radioimmunoassay Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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