NDLI: The gene encoding the T-cell surface protein T4 is located on human chromosome 12.

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The gene encoding the T-cell surface protein T4 is located on human chromosome 12.

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The gene encoding the T-cell surface protein T4 is located on human chromosome 12.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Isobe, M. Maddon, P. J. Littman, D. R. Axel, R. Croce, C. M. Huebner, K.
Abstract	The surface glycoproteins T4 and T8 define functionally distinct populations of T lymphocytes. We have obtained cDNA and genomic clones encoding the T4 molecule and used these as probes to determine the chromosomal location of this gene. Genomic blotting experiments, along with in situ hybridization analyses, indicate that the T4 gene resides on the short arm of human chromosome 12, at region p12-pter. Thus, the T4 gene is not linked to any known member of the immunoglobulin gene family, including its counterpart gene, T8, which resides on human chromosome 2 immediately distal to the immunoglobulin kappa locus.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Surface Genetics Chromosomes, Human, 6-12 And X Membrane Proteins Receptors, Virus T-Lymphocytes Physiology Antigens, Differentiation, T-Lymphocyte Chromosome Mapping DNA Hybrid Cells Nucleic Acid Hybridization Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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