NDLI: Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone.

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Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Poellinger, L. Gustafsson, J. A. Dong, Y. Okret, S.
Abstract	A cDNA clone for the rat glucocorticoid receptor (GR) was used to study mechanisms of GR mRNA regulation. Treatment of rat hepatoma culture cells with 0.5 microM dexamethasone caused a small, initial increase in the GR mRNA level after 6 hr as well as a 50% to 95% reduction of the GR mRNA level after 24 hr of incubation when studied by RNA blot hybridization. After 72 hr, the initial GR mRNA level was restored. The down-regulation of GR mRNA levels appears to be independent of protein synthesis, since it also was observed in the presence of cycloheximide. However, cycloheximide caused a 4-fold increase in intracellular levels of GR mRNA. Using an immunoprecipitation assay, we could demonstrate that the GR specifically interacts with a GR cDNA clone, which represents a 2.6-kilobase fragment of the 3' nontranslated region of the GR mRNA. Nuclease protection experiments indicate the presence of several internal GR-binding regions in the above fragment.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	16
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cloning, Molecular DNA Metabolism Dexamethasone Pharmacology RNA, Messenger Genetics Receptors, Glucocorticoid Transcription, Genetic Drug Effects Animals Cell Line DNA Restriction Enzymes Homeostasis Liver Neoplasms, Experimental Nucleic Acid Hybridization Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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