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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Urdal, D. L. Friend, D. Grabstein, K. Park, L. S. |
| Abstract | Radiolabeled recombinant murine B-cell-stimulatory factor 1 (BSF-1) was used to characterize receptors specific for this lymphokine on the surface of primary B and T cells and in vitro cell lines representing the B-cell, T-cell, mast cell, macrophage, and myelomonocytic lineages. BSF-1 binding was rapid and saturable at 4 degrees C and 37 degrees C with a slow dissociation rate. On all cell types examined, BSF-1 bound to a single class of high-affinity receptor (less than 2000 receptors per cell) with a Ka of 10(10)-10(11) M-1. Receptor expression on resting primary B and T cells was low (less than 100 receptors per cell), whereas activation with lipopolysaccharide or Con A produced a 5- to 10-fold increase in receptor numbers. Among a panel of lymphokines and growth hormones, only unlabeled BSF-1 was able to compete for the binding of 125I-labeled BSF-1. Affinity crosslinking experiments resulted in the identification on all cells tested of a receptor protein with an average Mr of 75,000. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 84 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1987-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Receptors, Mitogen Animals Binding, Competitive Cell Line Electrophoresis, Polyacrylamide Gel Growth Substances Metabolism Hormones Pharmacology Interleukin-4 Lymphokines Mice Mice, Inbred C57BL Molecular Weight Receptors, Interleukin-4 T-Lymphocytes, Cytotoxic Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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