NDLI: Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1987 Volume: 84 Issue: 24

Year: 1987 Volume: 84 Issue: 23

Year: 1987 Volume: 84 Issue: 22

Year: 1987 Volume: 84 Issue: 21

Year: 1987 Volume: 84 Issue: 20

Year: 1987 Volume: 84 Issue: 19

Year: 1987 Volume: 84 Issue: 18

Year: 1987 Volume: 84 Issue: 17

Year: 1987 Volume: 84 Issue: 16

Year: 1987 Volume: 84 Issue: 15

Year: 1987 Volume: 84 Issue: 14

Year: 1987 Volume: 84 Issue: 13

Year: 1987 Volume: 84 Issue: 12

Year: 1987 Volume: 84 Issue: 11

Year: 1987 Volume: 84 Issue: 10

Secretin stimulates cyclic AMP and inositol trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms.

Endonuclease IV of Escherichia coli is induced by paraquat.

Single acetylcholine receptor channel currents recorded at high hydrostatic pressures.

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles.

Calcium-dependent effect of the thymic polypeptide thymopoietin on the desensitization of the nicotinic acetylcholine receptor.

Monoclonal antibody analysis of keratin expression in the central nervous system.

Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.

Periodic crosslinking of microtubules by cytoplasmic microtubule-associated and microtubule-corset proteins from a trypanosomatid.

Detection of human DNA polymorphisms with a simplified denaturing gradient gel electrophoresis technique.

Isolation and characterization of the alpha-sialyl-beta-2,3-galactosyl-specific adhesin from fimbriated Escherichia coli.

Regulation of actomyosin ATPase activity by troponin-tropomyosin: effect of the binding of the myosin subfragment 1 (S-1).ATP complex.

Cytoskeletal association of human alpha-interferon-receptor complexes in interferon-sensitive and -resistant lymphoblastoid cells.

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

Growth factor(s) produced during infection with an adenovirus variant stimulates proliferation of nonestablished epithelial cells.

Protein import into chloroplasts requires a chloroplast ATPase.

Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.

Cloning and DNA sequence of the mercuric- and organomercurial-resistance determinants of plasmid pDU1358.

Sequences from a prokaryotic genome or the mouse dihydrofolate reductase gene can restore the import of a truncated precursor protein into yeast mitochondria.

Properties of the duplex DNA-dependent ATPase activity of Escherichia coli RecA protein and its role in branch migration.

Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells.

Cotranslational insertion of selenocysteine into formate dehydrogenase from Escherichia coli directed by a UGA codon.

Aberrant splicing events that are induced by proviral integration: implications for myb oncogene activation.

Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene.

RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.

The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

A high molecular weight component of the human tumor necrosis factor receptor is associated with cytotoxicity.

Structure and expression of human dihydropteridine reductase.

Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes.

Biosynthesis, glycosylation, and partial N-terminal amino acid sequence of the T-cell-activating protein TAP.

1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes.

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.

Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23.

Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta.

Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins.

Reaction of argininosuccinase with bromomesaconic acid: role of an essential lysine in the active site.

Purification, properties, and immunocytochemical localization of human liver peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.

Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells.

A molecular phylogeny of the hominoid primates as indicated by two-dimensional protein electrophoresis.

Molecular cloning and characterization of esterase-6, a serine hydrolase of Drosophila.

Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site.

Interferon gamma induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens.

Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.

Chimeric mouse-human IgG1 antibody that can mediate lysis of cancer cells.

Cholinergic phosphatidylinositol modulation of inhibitory, G protein-linked neurotransmitter actions: electrophysiological studies in rat hippocampus.

Accessible surface areas as a measure of the thermodynamic parameters of hydration of peptides.

Thyroid hormone regulates expression of a transfected alpha-myosin heavy-chain fusion gene in fetal heart cells.

Crystal structure of a snake venom cardiotoxin.

Synchrotron x-ray diffraction studies of actin structure during polymerization.

Temporal and tissue-specific expression of mouse ets genes.

A nonsense mutation causes hereditary goitre in the Afrikander cattle and unmasks alternative splicing of thyroglobulin transcripts.

Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins.

Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA.

Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen.

Immunoglobulin A stimulates growth of the extrahepatic bile duct in BALB/c mice.

Functional epithelial cell line cloned from rat parathyroid glands.

Chemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cells.

Cell patterning in pigment-chimeric eyes in Xenopus: germinal transplants and their contributions to growth of the pigmented retinal epithelium.

Geographic dialects in blind mole rats: role of vocal communication in active speciation.

Random cloning of genes from mouse chromosome 17.

Purification and characterization of rat liver nuclear thyroid hormone receptors.

Linkage of the Wiskott-Aldrich syndrome with polymorphic DNA sequences from the human X chromosome.

Androstenedione may organize or activate sex-reversed traits in female spotted hyenas.

Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis.

Neurofilament gene expression: a major determinant of axonal caliber.

Multiple neuropeptides in cholinergic motor neurons of Aplysia: evidence for modulation intrinsic to the motor circuit.

Quinolinic acid phosphoribosyltransferase: preferential glial localization in the rat brain visualized by immunocytochemistry.

gamma-Aminobutyric acid exerts a local inhibitory action on the axon terminal of bipolar cells: evidence for negative feedback from amacrine cells.

Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor.

Human immunodeficiency virus can productively infect cultured human glial cells.

Differential regulation of colony-stimulating factors and interleukin 2 production by cyclosporin A.

Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.

Lymphocyte major histocompatibility complex-encoded class II structures may act as sperm receptors.

Working principles in the immune system implied by the 'peptidic self' model.

Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity.

Specific inhibition of Trypanosoma cruzi neuraminidase by the human plasma glycoprotein 'cruzin'.

Properties of a genetically engineered G domain of elongation factor Tu.

Apparent lack of discrimination in the reading of certain codons in Mycoplasma mycoides.

lac repressor blocks in vivo transcription of lac control region DNA.

Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy.

Firefly luciferase is targeted to peroxisomes in mammalian cells.

Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

A family of short, interspersed repeats is associated with tandemly repetitive DNA in the human genome.

Comparative anatomy of the human APRT gene and enzyme: nucleotide sequence divergence and conservation of a nonrandom CpG dinucleotide arrangement.

Sequence analysis of spontaneous mutations in a shuttle vector gene integrated into mammalian chromosomal DNA.

Development of a monoclonal antibody specifically reactive to gastrointestinal goblet cells.

Neuropeptide Y-like immunoreactivity in rat cranial parasympathetic neurons: coexistence with vasoactive intestinal peptide and choline acetyltransferase.

Initial localization of the acoustic conditioned stimulus projection system to the cerebellum essential for classical eyelid conditioning.

Year: 1987 Volume: 84 Issue: 9

Year: 1987 Volume: 84 Issue: 8

Year: 1987 Volume: 84 Issue: 7

Year: 1987 Volume: 84 Issue: 6

Year: 1987 Volume: 84 Issue: 5

Year: 1987 Volume: 84 Issue: 4

Year: 1987 Volume: 84 Issue: 3

Year: 1987 Volume: 84 Issue: 2

Year: 1987 Volume: 84 Issue: 1

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eaton, D. L. Kohr, W. J. Lawn, R. M. Mclean, J. W. Miller, C. G. Xu, Q. T. Scanu, A. M. Fless, G. M.
Abstract	Apolipoprotein(a) [apo(a)] is a glycoprotein with Mr approximately equal to 280,000 that is disulfide linked to apolipoprotein B in lipoprotein(a) particles. Elevated plasma levels of lipoprotein(a) are correlated with atherosclerosis. Partial amino acid sequence of apo(a) shows that it has striking homology to plasminogen. Plasminogen is a plasma serine protease zymogen that consists of five homologous and tandemly repeated domains called kringles and a trypsin-like protease domain. The amino-terminal sequence obtained for apo(a) is homologous to the beginning of kringle 4 but not the amino terminus of plasminogen. Apo(a) was subjected to limited proteolysis by trypsin or V8 protease, and fragments generated were isolated and sequenced. Sequences obtained from several of these fragments are highly (77-100%) homologous to plasminogen residues 391-421, which reside within kringle 4. Analysis of these internal apo(a) sequences revealed that apo(a) may contain at least two kringle 4-like domains. A sequence obtained from another tryptic fragment also shows homology to the end of kringle 4 and the beginning of kringle 5. Sequence data obtained from two tryptic fragments show homology with the protease domain of plasminogen. One of these sequences is homologous to the sequences surrounding the activation site of plasminogen. Plasminogen is activated by the cleavage of a specific arginine residue by urokinase and tissue plasminogen activator; however, the corresponding site in apo(a) is a serine that would not be cleaved by tissue plasminogen activator or urokinase. Using a plasmin-specific assay, no proteolytic activity could be demonstrated for lipoprotein(a) particles. These results suggest that apo(a) contains kringle-like domains and an inactive protease domain.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	84
Language	English
Publisher	National Academy of Sciences
Publisher Date	1987-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apolipoproteins A Blood Plasminogen Amino Acid Sequence Genetics Isolation & Purification Arteriosclerosis Peptide Fragments Sequence Homology, Nucleic Acid Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in