NDLI: A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1987 Volume: 84 Issue: 24

Year: 1987 Volume: 84 Issue: 23

Year: 1987 Volume: 84 Issue: 22

Year: 1987 Volume: 84 Issue: 21

Year: 1987 Volume: 84 Issue: 20

Year: 1987 Volume: 84 Issue: 19

Year: 1987 Volume: 84 Issue: 18

Year: 1987 Volume: 84 Issue: 17

Year: 1987 Volume: 84 Issue: 16

Year: 1987 Volume: 84 Issue: 15

Year: 1987 Volume: 84 Issue: 14

Year: 1987 Volume: 84 Issue: 13

Year: 1987 Volume: 84 Issue: 12

Year: 1987 Volume: 84 Issue: 11

Profile of the continuous antigenic regions on the extracellular part of the alpha chain of an acetylcholine receptor.

5'-structural analysis of genes encoding polymorphic antigens of chemically induced tumors.

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin.

A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation.

Potentiation of the calcium-channel currents of internally perfused mammalian heart cells by repetitive depolarization.

Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.

Effector and suppressor circuits of the immune response are activated in vivo by different mechanisms.

Heparin sequences in the heparan sulfate chains of an endothelial cell proteoglycan.

Identification of Fc and F(ab')2 IgG receptors on human platelets.

Regulation of insulin-like growth factor II receptors by growth hormone and insulin in rat adipocytes.

Complementation of areA- regulatory gene mutations of Aspergillus nidulans by the heterologous regulatory gene nit-2 of Neurospora crassa.

Turning (Ir gene) low responders into high responders by antibody manipulation of the developing immune system.

Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.

Nucleoside triphosphate-dependent DNA-binding properties of mos protein.

Analysis and in vivo disruption of the gene coding for calmodulin in Schizosaccharomyces pombe.

Endogenous inhibitor for calcium-dependent cysteine protease contains four internal repeats that could be responsible for its multiple reactive sites.

Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes.

Molecular cloning of cDNAs of human liver and placenta NADH-cytochrome b5 reductase.

Helicase properties of the Escherichia coli UvrAB protein complex.

Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template.

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer.

Replication of mini-P1 plasmid DNA in vitro requires two initiation proteins, encoded by the repA gene of phage P1 and the dnaA gene of Escherichia coli.

Ubiquitin has intrinsic proteolytic activity: implications for cellular regulation.

Identification of the receptor for erythropoietin by cross-linking to Friend virus-infected erythroid cells.

Regulation of the host range of human papovavirus JCV.

Prostaglandin F2 alpha stimulates phosphatidylinositol 4,5-bisphosphate hydrolysis and mobilizes intracellular Ca2+ in bovine luteal cells.

The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.

Nonpolarized secretion of truncated forms of the influenza hemagglutinin and the vesicular stomatitus virus G protein from MDCK cells.

Nucleotide sequence and evolution of ETn elements.

Characterization of five partial deletions of the factor VIII gene.

Genomic organization of the mouse T-cell receptor beta-chain gene family.

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

Varicella-zoster virus as a live vector for the expression of foreign genes.

The narL gene product activates the nitrate reductase operon and represses the fumarate reductase and trimethylamine N-oxide reductase operons in Escherichia coli.

Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina.

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187.

Kinds of mutations formed when a shuttle vector containing adducts of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene replicates in human cells.

Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning.

T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.

Assessment of antigen-specific receptor function of surface immunoglobulin M and D with identical hapten specificity.

Protein-nucleotide contacts in the immunoglobulin heavy-chain promoter region.

The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone.

The retinal ganglion cell mosaic defines orientation columns in striate cortex.

Expression of the Saccharomyces cerevisiae glycoprotein invertase in mouse fibroblasts: glycosylation, secretion, and enzymatic activity.

TUF, the yeast DNA-binding factor specific for UASrpg upstream activating sequences: identification of the protein and its DNA-binding domain.

Soluble factors stimulating secretory protein translocation in bacteria and yeast can substitute for each other.

Insulin-like synergistic stimulation of DNA synthesis in Swiss 3T3 cells by the BSC-1 cell-derived growth inhibitor related to transforming growth factor type beta.

Spectrum of cisplatin-induced mutations in Escherichia coli.

Corticotropin-releasing factor in the olivocerebellar tract of rats: demonstration by light- and electron-microscopic immunohistochemistry and in situ hybridization histochemistry.

Telencephalon-specific antigen identified by monoclonal antibody.

Permeability measurements with closed vesicles from rat liver nuclear envelopes.

Isolation and complete amino acid sequence of human thymopoietin and splenin. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 84 Issue: 11)

Resolution of human transcription factor TFIIIC into two functional components.

Model of anaphase chromosome movement based on polymer-guided diffusion.

Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate.

Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.

Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.

Anti-idiotypic antibodies as probes of protein active sites: application to cholera toxin subunit B.

Tunicamycin tightens the glucose- and D-allose-mediated control of hexose transport in a metabolic fibroblast mutant.

Effect of lipid surface charges on the purple-to-blue transition of bacteriorhodopsin.

Spectral and kinetic evidence for the existence of two forms of bathorhodopsin.

Integral membrane proteins significantly decrease the molecular motion in lipid bilayers: a deuteron NMR relaxation study of membranes containing myelin proteolipid apoprotein.

Gap junction assembly in the preimplantation mouse conceptus is independent of microtubules, microfilaments, cell flattening, and cytokinesis.

A cellular enhancer of retrovirus gene expression in embryonal carcinoma cells.

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.

Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.

Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

Absence of cytotoxic antibody to human immunodeficiency virus-infected cells in humans and its induction in animals after infection or immunization with purified envelope glycoprotein gp120.

Prematurity, hypogammaglobulinemia, and neuropathology with human immunodeficiency virus (HIV) infection.

Transmission in NFS/N mice of the heritable spongiform encephalopathy associated with the gray tremor mutation.

Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees.

Expression of functionally active human antithrombin III.

Endogenous adenosine and adenosine receptors localized to ganglion cells of the retina.

Neurons in the dorsal motor nucleus of the vagus nerve are excited by oxytocin in the rat but not in the guinea pig.

Induction of murine interleukin 1: stimuli and responsive primary cells.

Isolation of a T-cell clone that reacts with both antigen and anti-idiotype: evidence for anti-idiotype as internal image for antigen at the T-cell level.

Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny.

Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor.

Monoclonal anti-idiotypic antibody mimics the CD4 receptor and binds human immunodeficiency virus.

Year: 1987 Volume: 84 Issue: 10

Year: 1987 Volume: 84 Issue: 9

Year: 1987 Volume: 84 Issue: 8

Year: 1987 Volume: 84 Issue: 7

Year: 1987 Volume: 84 Issue: 6

Year: 1987 Volume: 84 Issue: 5

Year: 1987 Volume: 84 Issue: 4

Year: 1987 Volume: 84 Issue: 3

Year: 1987 Volume: 84 Issue: 2

Year: 1987 Volume: 84 Issue: 1

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Burgess-cassler, A. Hinrichsen, R. D. Kung, C. Watterson, D. M. Schaefer, W. H. Blair, I. A.
Abstract	The Paramecium mutant, pantophobiac A, has a defect that results in an in vivo loss of calcium-dependent potassium efflux channel activity. This defect is corrected fully by the microinjection of wild-type Paramecium calmodulin into pantophobiac A cells and is partially restored by calmodulins from other organisms, but it cannot be restored by microinjection of pantophobiac calmodulin. Overall, these results suggested that wild-type Paramecium calmodulin has unique features that allow it to restore fully a normal phenotype and that the defect in pantophobiac A might be an altered calmodulin molecule. Previous studies established the amino acid sequence of wild-type calmodulin and showed that Paramecium calmodulin has several differences from other calmodulins, including the presence of dimethyllysine at residue 13. To test directly the possibility that calmodulin from the pantophobiac mutant might be altered, we purified the mutant calmodulin and compared its properties to those of wild-type Paramecium calmodulin. We found one amino acid sequence difference between the two Paramecium calmodulins: a phenylalanine in the mutant protein, instead of a serine, at residue 101. This change is at a calcium-liganding residue in the third calcium-binding loop. These and previous studies demonstrate that comparatively subtle changes in the structure of calmodulin can result in quantitative alterations in in vivo activity, provide insight into the in vivo roles of calmodulin and the regulation of ion channels, and demonstrate that functional alterations of calmodulin are not necessarily lethal.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	84
Language	English
Publisher	National Academy of Sciences
Publisher Date	1987-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Pharmacology Calmodulin Physiology Ion Channels Mutation Paramecium Potassium Metabolism Amino Acid Sequence Amino Acids Animals Genetics Drug Effects Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in