NDLI: Gene overlap and site-specific attenuation of transcription of the viral polymerase L gene of human respiratory syncytial virus.

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Gene overlap and site-specific attenuation of transcription of the viral polymerase L gene of human respiratory syncytial virus.

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Gene overlap and site-specific attenuation of transcription of the viral polymerase L gene of human respiratory syncytial virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Johnson, P. R. Buckler-white, A. J. Collins, P. L. Olmsted, R. A. Spriggs, M. K.
Abstract	Sequence analysis of the gene encoding polymerase L protein of respiratory syncytial virus showed that L-gene transcription initiates within its upstream neighbor, the gene encoding the 22-kDa protein 22K. This is an exception to the canonical mode of sequential transcription of nonoverlapping genes described for other nonsegmented negative-strand RNA viruses. As a consequence of the gene overlap, the termination/polyadenylylation signal for the 22K gene is located at nucleotides 56-68 within the L gene. L-gene transcription yielded two RNAs: an abundant, truncated, polyadenylylated transcript resulting from termination at the internal signal and a markedly less abundant large polyadenylylated transcript representing the complete L gene. This result showed that the internal termination/polyadenylylation signal is an attenuator of L-gene transcription.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	84
Language	English
Publisher	National Academy of Sciences
Publisher Date	1987-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Viral Respiratory Syncytial Viruses Genetics Transcription, Genetic Viral Proteins Amino Acid Sequence Poly A Metabolism RNA RNA, Messenger RNA, Viral Enzymology Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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