NDLI: Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

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Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

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Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fahey, D. Reich, N. Darnell, J. E. Evans, B. Levy, D. Knight, E.
Abstract	A human gene encoding an interferon-induced 15-kDa protein has been isolated from a genomic library. The gene appears to be single-copy and is composed of two exons, the first of which contains the ATG translation initiation codon. In vitro nuclear run-on assays showed that the transcription rate of the gene is stimulated after interferon treatment. To analyze transcriptional regulatory sequences, we constructed recombinant plasmids for use in transient transfection assays of HeLa cells. Constructs containing 115 nucleotides 5' to the transcription initiation site were found to be fully inducible by interferon. Assays of deletion mutants identified a critical element for interferon induction located between -115 and -96, just upstream of the 'CCAAT box.' Moreover, a DNA fragment including this region can confer interferon inducibility on a heterologous promoter (thymidine kinase) when cloned in either orientation upstream of the gene or downstream of the gene. These are properties characteristic of an enhancer element that is active only after treatment with interferon. This regulatory sequence may be shared by a group of interferon-induced genes, since a very similar sequence is present within the functional region near the RNA start site of another interferon-induced gene.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	84
Language	English
Publisher	National Academy of Sciences
Publisher Date	1987-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Enhancer Elements, Genetic Genes, Regulator Interferon Type I Pharmacology Proteins Genetics Transcription, Genetic Drug Effects Amino Acid Sequence Gene Expression Regulation Genes HeLa Cells Molecular Weight Promoter Regions, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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