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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cundy, K. C. Ames, B. N. Kohen, R. Yamamoto, Y. |
| Description | Author Affiliation: Kohen R ( Department of Biochemistry, University of California, Berkeley 94720.); |
| Abstract | Carnosine, homocarnosine, and anserine are present in high concentrations in the muscle and brain of many animals and humans. However, their exact function is not clear. The antioxidant activity of these compounds has been examined by testing their peroxyl radical-trapping ability at physiological concentrations. Carnosine, homocarnosine, anserine, and other histidine derivatives all showed antioxidant activity. All of these compounds showing peroxyl radical-trapping activity were also electrochemically active as reducing agents in cyclic voltammetric measurements. Furthermore, carnosine inhibited the oxidative hydroxylation of deoxyguanosine induced by ascorbic acid and copper ions. Other roles of carnosine, such as chelation of metal ions, quenching of singlet oxygen, and binding of hydroperoxides, are also discussed. The data suggest a role for these histidine-related compounds as endogenous antioxidants in brain and muscle. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 9 |
| Volume Number | 85 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1988-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Anserine Pharmacology Antioxidants Brain Metabolism Carnosine Dipeptides Muscles Amidines Azo Compounds Analogs & Derivatives Chromatography, High Pressure Liquid Deoxyguanosine Electrochemistry Free Radicals Histidine Lipid Peroxides Nitriles Structure-Activity Relationship Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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