NDLI: Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1988 Volume: 85 Issue: 24

Year: 1988 Volume: 85 Issue: 23

Year: 1988 Volume: 85 Issue: 22

Year: 1988 Volume: 85 Issue: 21

Year: 1988 Volume: 85 Issue: 20

Year: 1988 Volume: 85 Issue: 19

Year: 1988 Volume: 85 Issue: 18

Year: 1988 Volume: 85 Issue: 17

Year: 1988 Volume: 85 Issue: 16

Year: 1988 Volume: 85 Issue: 15

Year: 1988 Volume: 85 Issue: 14

Year: 1988 Volume: 85 Issue: 13

Year: 1988 Volume: 85 Issue: 12

Putative structure and functions of a poly-beta-hydroxybutyrate/calcium polyphosphate channel in bacterial plasma membranes.

Evidence for a cAMP-dependent nuclear factor capable of interacting with a specific region of a eukaryotic gene.

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers.

Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.

HLA class I molecules are associated with CD1a heavy chains on normal human thymus cells.

Infection of rabbit T-cell and macrophage lines with human immunodeficiency virus.

Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees.

Three-dimensional model of the capsid proteins of two biologically different Theiler virus strains: clustering of amino acid difference identifies possible locations of immunogenic sites on the virion.

Renal autoimmune epitope of group A streptococci specified by M protein tetrapeptide Ile-Arg-Leu-Arg.

High levels of heterodisperse RNAs accumulate in T cells infected with human immunodeficiency virus and in normal thymocytes.

Thy-1-mediated regulation of a low-threshold transient calcium current in cultured sensory neurons.

Cooperative DNA binding of heterologous proteins: evidence for contact between the cyclic AMP receptor protein and RNA polymerase.

Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor.

Synthetic peptides as substrates and inhibitors of a retroviral protease.

Transcription of oxygen-regulated photosynthetic genes requires DNA gyrase in Rhodobacter capsulatus.

cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates.

Escherichia coli host factor for site-specific DNA inversion: cloning and characterization of the fis gene.

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle.

Specific insertion and deletion of insertion sequence 1-like DNA element causes the reversible expression of the virulence capsular antigen Vi of Citrobacter freundii in Escherichia coli.

Rat L (long interspersed repeated DNA) elements contain guanine-rich homopurine sequences that induce unpairing of contiguous duplex DNA.

Recognition of galactosylgloboside by monoclonal antibodies derived from patients with primary lung cancer.

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

Beta 2-adrenergic mechanisms in experimental arthritis.

A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.

Structural analysis of the 5' flanking region of the beta-globin gene in African sickle cell anemia patients: further evidence for three origins of the sickle cell mutation in Africa.

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

Rapid desensitization of glutamate receptors in vertebrate central neurons. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 85 Issue: 12)

Putative metabolites derived from dietary combinations of calcium glucarate and N-(4-hydroxyphenyl)retinamide act synergistically to inhibit the induction of rat mammary tumors by 7,12-dimethylbenz[a]anthracene.

Trans-activation of the human immunodeficiency virus long terminal repeat sequences, expressed in an adenovirus vector, by the adenovirus E1A 13S protein.

Kinetics of gamma interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages.

Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines.

No strict alignment is required between a transcriptional activator binding site and the 'TATA box' of a yeast gene.

Stress proteins are immune targets in leprosy and tuberculosis.

Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.

Extracellular control of spore formation in Bacillus subtilis.

Evolution of competitive ability in Drosophila by density-dependent natural selection.

A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.

Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation.

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis.

Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype.

Characterization of a zinc blotting technique: evidence that a retroviral gag protein binds zinc.

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

Characterization of frequent deletions causing steroid 21-hydroxylase deficiency.

Differential ability of B cells specific for external vs. internal influenza virus proteins to respond to help from influenza virus-specific T-cell clones in vivo.

Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro.

Dual effects of serotonin on a voltage-gated conductance in lymphocytes.

Structure of chloramphenicol acetyltransferase at 1.75-A resolution.

Aspartic acid substitutions affect proton translocation by bacteriorhodopsin.

Mutant 16S ribosomal RNA: a codon-specific translational suppressor.

A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer.

Codon choice and gene expression: synonymous codons differ in their ability to direct aminoacylated-transfer RNA binding to ribosomes in vitro.

Malignant transformation by ras and other oncogenes produces common alterations in inositol phospholipid signaling pathways.

Use of site-directed mutagenesis to elucidate the role of arginine-166 in the catalytic mechanism of alkaline phosphatase.

NIH-3T3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca2+ mobilization.

Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages.

DNA base sequence changes and sequence specificity of bromodeoxyuridine-induced mutations in mammalian cells.

Site-specific binding of viral plus single-stranded RNA to replicase-containing open virus-like particles of yeast.

Dominant negative protein kinase mutations that confer a G1 arrest phenotype.

Immunological identification of a high molecular weight protein as a candidate for the product of the Duchenne muscular dystrophy gene.

High-resolution 13C NMR study of pressure effects on the main phase transition in L-alpha-dipalmitoyl phosphatidylcholine vesicles.

Crystal and molecular structure of didemnin B, an antiviral and cytotoxic depsipeptide.

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains.

The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.

Isolation of a Bacillus thuringiensis RNA polymerase capable of transcribing crystal protein genes.

Three-dimensional structure of carbamoyl phosphate and succinate bound to aspartate carbamoyltransferase.

Primary structure of the human follistatin precursor and its genomic organization.

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

Avian reovirus mRNAs are nonfunctional in infected mouse cells: translational basis for virus host-range restriction.

Probing the salt bridge in the dihydrofolate reductase-methotrexate complex by using the coordinate-coupled free-energy perturbation method.

Regulation of the surface pressure of lipid monolayers and bilayers by the activity of water: derivation and application of an equation of state.

Energetics of the structure of the four-alpha-helix bundle in proteins.

Negative regulation of DNA synthesis in early erythropoietic progenitor cells (BFU-E) by a protein purified from the medium of C57BL/6 mouse marrow cells.

Heterotypic and homotypic associations between the nuclear lamins: site-specificity and control by phosphorylation.

Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors.

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing.

Codon preference is but an illusion created by the construction principle of coding sequences.

Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.

Reversal of the metastatic phenotype in Lewis lung carcinoma cells after transfection with syngeneic H-2Kb gene.

Endogenous adenosine and hemorrhagic shock: effects of caffeine administration or caffeine withdrawal.

Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.

Background light and the contrast gain of primate P and M retinal ganglion cells.

VAMP-1: a synaptic vesicle-associated integral membrane protein.

Ion transport by the Na-Ca exchange in isolated rod outer segments.

D1-type dopamine receptors inhibit growth cone motility in cultured retina neurons: evidence that neurotransmitters act as morphogenic growth regulators in the developing central nervous system. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 85 Issue: 12)

Year: 1988 Volume: 85 Issue: 11

Year: 1988 Volume: 85 Issue: 10

Year: 1988 Volume: 85 Issue: 9

Year: 1988 Volume: 85 Issue: 8

Year: 1988 Volume: 85 Issue: 7

Year: 1988 Volume: 85 Issue: 6

Year: 1988 Volume: 85 Issue: 5

Year: 1988 Volume: 85 Issue: 4

Year: 1988 Volume: 85 Issue: 3

Year: 1988 Volume: 85 Issue: 2

Year: 1988 Volume: 85 Issue: 1

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cooper, J. A. Macauley, A.
Description	Author Affiliation: Cooper JA ( Department of Cell Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.);
Abstract	The product of the protooncogene c-src is a protein-tyrosine kinase, p60c-src, that is normally inhibited by phosphorylation at a tyrosine residue close to the C terminus (Tyr-527). If activated by dephosphorylation of Tyr-527, or by other means, p60c-src becomes phosphorylated at a tyrosine residue in the catalytic domain (Tyr-416). To test whether either or both of these tyrosines can be phosphorylated by p60c-src itself, we have created four mutations in c-src. One mutant product can receive but cannot donate phosphate, and other mutants are capable of catalysis but lack phosphorylation sites. The mutant genes were expressed singly or in combination in yeast. Analysis of the phosphorylation of mutant p60c-src in the yeast cells and in immunoprecipitates showed that p60c-src molecules can phosphorylate each other at Tyr-416 and -527. Prohibiting intramolecular phosphorylation had little effect on reaction rates and extents, suggesting that intermolecular phosphorylation predominates. If the same situation pertains in the milieu of the vertebrate fibroblast, phosphorylation of one p60c-src by another at Tyr-416 or -527 could permit positive or negative autoregulation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Protein Kinases Metabolism Proto-Oncogene Proteins Genetics Proto-Oncogenes Homeostasis Mutation Phosphorylation Proto-Oncogene Proteins Pp60(c-src) Saccharomyces Cerevisiae Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in