NDLI: Genetic instability in Drosophila melanogaster: P-element mutagenesis by gene conversion.

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Genetic instability in Drosophila melanogaster: P-element mutagenesis by gene conversion.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Geyer, P. K. Corces, V. G. Richardson, K. L. Green, M. M.
Description	Author Affiliation: Geyer PK ( Department of Biology, Johns Hopkins University, Baltimore, MD 21218.);
Abstract	We report the molecular characterization of several P element-induced mutations and their revertants at the yellow (y) locus of Drosophila melanogaster. One of the mutants analyzed, y76d28, results from the insertion of a P element into the 5'-transcribed, untranslated portion of the y gene. Sequence analysis of several revertants of y76d28 shows that P excision occurs imprecisely. These events result in insertion of additional ATG codons in the y locus mRNA but are without phenotypic effect. In addition, we describe the molecular structure of P-associated mutations induced in a near wild-type revertant of y76d28 that carries an internally deleted 0.4-kilobase P element in the 5' noncoding region. Sequence analysis of two of these mutants demonstrates that they arose as a result of the integration of a larger P element at the exact location as in the parental stock without the 8-base-pair additional duplication associated with P insertions. The phenotype of these y alleles is dependent on the size and orientation of the integrated P element. We infer that P-element replacement in these mutants has occurred by a recombination/gene conversion mechanism.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Drosophila Melanogaster Genetics Gene Conversion Mutation Alleles Animals DNA Restriction Enzymes DNA Transposable Elements Molecular Sequence Data Nucleotide Mapping Transcription, Genetic Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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