NDLI: Regulation of the low density lipoprotein receptor and hydroxymethylglutaryl coenzyme A reductase genes by protein kinase C and a putative negative regulatory protein.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1989 Volume: 86 Issue: 24

Year: 1989 Volume: 86 Issue: 23

Year: 1989 Volume: 86 Issue: 22

Year: 1989 Volume: 86 Issue: 21

Year: 1989 Volume: 86 Issue: 20

Year: 1989 Volume: 86 Issue: 19

Year: 1989 Volume: 86 Issue: 18

Year: 1989 Volume: 86 Issue: 17

Year: 1989 Volume: 86 Issue: 16

Year: 1989 Volume: 86 Issue: 15

Year: 1989 Volume: 86 Issue: 14

Year: 1989 Volume: 86 Issue: 13

Year: 1989 Volume: 86 Issue: 12

Year: 1989 Volume: 86 Issue: 11

Year: 1989 Volume: 86 Issue: 10

Year: 1989 Volume: 86 Issue: 9

Year: 1989 Volume: 86 Issue: 8

Year: 1989 Volume: 86 Issue: 7

Year: 1989 Volume: 86 Issue: 6

Year: 1989 Volume: 86 Issue: 5

Year: 1989 Volume: 86 Issue: 4

Growth-rate-dependent regulation of 6-phosphogluconate dehydrogenase level mediated by an anti-Shine-Dalgarno sequence located within the Escherichia coli gnd structural gene.

Expression of haptoglobin-related protein and its potential role as a tumor antigen.

Regulation of interleukin 1 and its receptor in human keratinocytes.

Mitogenicity and down-regulation of high-affinity interleukin 2 receptor by YTA-1 and YTA-2, monoclonal antibodies that recognize 75-kDa molecules on human large granular lymphocytes.

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

Production and characterization of monoclonal antibodies identifying breast tumor-associated antigens.

Low density lipoprotein undergoes oxidative modification in vivo.

Growth hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover.

Identification of an assembly domain in the small subunit of ribulose-1,5-bisphosphate carboxylase.

Sequential expression and cooperative interaction of c-Ha-ras and c-erbB genes in in vivo chemical carcinogenesis.

Juvenile hormone bisepoxide biosynthesis in vitro by the ring gland of Drosophila melanogaster: a putative juvenile hormone in the higher Diptera.

Amino acid polymorphisms for esterase-6 in Drosophila melanogaster.

Identification of covalently linked trimeric and tetrameric D domains in crosslinked fibrin.

Molecular cloning and sequence of cDNA encoding the plasma membrane proton pump (H+-ATPase) of Arabidopsis thaliana.

Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16.

Regulation of duodenal bicarbonate secretion during stress by corticotropin-releasing factor and beta-endorphin.

Identification of a phorbol ester-repressible v-src-inducible gene.

Transduction heats in retinal rods: tests of the role of cGMP by pyroelectric calorimetry.

Respiratory burst oxidase of fertilization.

Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli.

Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.

Low density of sodium channels supports action potential conduction in axons of neonatal rat optic nerve.

Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.

In vitro reconstitution of osmoregulated expression of proU of Escherichia coli.

Transmembrane signal transduction in bacterial chemotaxis involves ligand-dependent activation of phosphate group transfer.

Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factors.

Cellular differentiation in the emerging fetal rat small intestinal epithelium: mosaic patterns of gene expression.

Sequence of the Lyb-2 B-cell differentiation antigen defines a gene superfamily of receptors with inverted membrane orientation.

Helodermin-like peptides in thyroid C cells: stimulation of thyroid hormone secretion and suppression of calcium incorporation into bone.

Molecular and cellular responses of islets during perturbations of glucose homeostasis determined by in situ hybridization histochemistry.

Immunocytochemical localization of the beta I subspecies of protein kinase C in rat brain.

Human immunodeficiency virus type 1 negative factor is a transcriptional silencer.

Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression.

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

Highly attenuated vaccinia virus mutants for the generation of safe recombinant viruses.

Identity of human B-cell line cytotoxic lymphokine with tumor necrosis factor type beta.

Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease.

Model of the interactions of calichemicin gamma 1 with a DNA fragment from pBR322.

Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines.

Binding of hormone accelerates the kinetics of glucocorticoid and progesterone receptor binding to DNA.

Regulation of the low density lipoprotein receptor and hydroxymethylglutaryl coenzyme A reductase genes by protein kinase C and a putative negative regulatory protein.

UV-induced DNA-binding proteins in human cells.

Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format.

Identifying protein-binding sites from unaligned DNA fragments.

Cooperative interaction of Agrobacterium VirE2 protein with single-stranded DNA: implications for the T-DNA transfer process.

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.

Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence.

Dynamic Monte Carlo study of the folding of a six-stranded Greek key globular protein.

Primary structure of cucumber (Cucumis sativus) ascorbate oxidase deduced from cDNA sequence: homology with blue copper proteins and tissue-specific expression.

Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types.

Fourier analysis of cell motility: correlation of motility with metastatic potential.

Targeting of a chromosomal protein to the nucleus and to lampbrush chromosome loops.

Divergent evolution of part of the involucrin gene in the hominoids: unique intragenic duplications in the gorilla and human.

Recovery of induced mutations for X chromosome-linked muscular dystrophy in mice.

Rapid detection of ultraviolet-induced reversion of an amber mutation in mouse L cells.

Chromosomes of older humans are more prone to aminopterine-induced breakage.

Anomalous and selective DNA mutations of the Old World monkey alpha-globin genes.

Conservation of structural and functional domains in complement component C3 of Xenopus and mammals.

Sulfation of tyrosine residues increases activity of the fourth component of complement.

Mature human eosinophils have the capacity to express HLA-DR.

Hippocampal specialization of food-storing birds.

Dopamine turnover and glutathione oxidation: implications for Parkinson disease.

Trigeminovascular fibers increase blood flow in cortical gray matter by axon reflex-like mechanisms during acute severe hypertension or seizures.

The two subunits of the human asialoglycoprotein receptor have different fates when expressed alone in fibroblasts

Year: 1989 Volume: 86 Issue: 3

Year: 1989 Volume: 86 Issue: 2

Year: 1989 Volume: 86 Issue: 1

Specific photoaffinity labeling of two plasma membrane polypeptides with an azido auxin.

Phytochrome induces changes in the immunodetectable level of a wall peroxidase that precede growth changes in maize seedlings.

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Regulation of the low density lipoprotein receptor and hydroxymethylglutaryl coenzyme A reductase genes by protein kinase C and a putative negative regulatory protein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Deeb, S. S. Auwerx, J. H. Chait, A.
Description	Author Affiliation: Auwerx JH ( Department of Medicine, University of Washington, Seattle 98195.);
Abstract	Transcription of the low density lipoprotein receptor (LDL-R) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase genes was rapidly and transiently induced (8.5- and 2.3-fold, respectively) early during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of the human monocytic leukemia cell line THP-1. The levels of mRNA coding for LDL-R and HMG-CoA reductase increased soon after induction, reached a maximum (12- and 7-fold increase, respectively) in 2-3 hr, and then rapidly returned to the low constitutive levels observed before induction. The stability of LDL-R mRNA did not change significantly during differentiation, whereas that of HMG-CoA reductase mRNA decreased by about 5-fold 6 hr after the addition of PMA. Transcriptional induction of both LDL-R and HMG-CoA reductase genes (5.6- and 2-fold, respectively) was also observed when undifferentiated cells were treated with cycloheximide (CHX), resulting in a transient increase in steady-state mRNA (7- and 3-fold, respectively). These results suggest that expression of the two genes is maintained at low constitutive levels in uninduced THP-1 cells by a protein with a short half-life. Superinduction of both genes occurred when PMA and CHX were added simultaneously. The induction of LDL-R and HMG-CoA reductase mRNAs during early macrophage differentiation is mediated by protein kinase C. It is hypothesized that protein kinase C acts directly or indirectly to inactivate the labile negative regulatory protein. Induction of LDL-R mRNA was also observed when the human hepatocarcinoma cell line Hep G2 was treated with PMA and CHX, suggesting that this mechanism of regulation may exist in several cell types.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Regulator Genes Hydroxymethylglutaryl CoA Reductases Genetics Protein Kinase C Metabolism Receptors, LDL Transcription, Genetic Cell Line Drug Effects Kinetics RNA, Messenger Biosynthesis Tetradecanoylphorbol Acetate Pharmacology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in