NDLI: Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.

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Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.

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Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Brubaker, P. L. Drucker, D. J.
Description	Author Affiliation: Drucker DJ ( Department of Medicine, Toronto General Hospital, University of Toronto, ON, Canada.);
Abstract	Expression of the gene encoding preproglucagon gives rise to different glucagon-related peptides in the pancreas and intestine. Glucagon gene expression is regulated by a protein kinase C-dependent pathway in rat islet cell lines, whereas activation of the adenylate cyclase pathway in islet cell lines is without effect. To elucidate the factors important for the control of proglucagon biosynthesis in the intestine, we have studied proglucagon gene expression and proglucagon biosynthesis in rat intestine. Analysis of intestinal cDNA clones encoding preproglucagon indicated that pancreatic and intestinal glucagon mRNA transcripts were identical. The regulation of proglucagon gene expression in rat intestine differed markedly from that previously observed in islet cell lines. Phorbol esters increased the secretion of glucagon-like immunoreactive peptides (GLI) but had no effect on proglucagon mRNA levels in rat intestinal cells. Bombesin also increased the secretion of GLI without affecting proglucagon mRNA levels or biosynthesis. In contrast, dibutyryl cyclic AMP, forskolin, and cholera toxin increased both proglucagon mRNA levels and GLI biosynthesis and secretion, suggesting that proglucagon gene expression in the intestine is regulated by a cyclic AMP-dependent pathway. These observations suggest that tissue-specific differences in both the regulation of proglucagon gene expression and the posttranslational processing of proglucagon contribute to the diversity of glucagon gene expression.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bucladesine Pharmacology Cyclic AMP Physiology Gene Expression Regulation Drug Effects Genes Glucagon Genetics Intestines Metabolism Protein Precursors Animals Bombesin Cholera Toxin Colforsin DNA Isolation & Purification Fetus Kinetics Molecular Sequence Data Proglucagon RNA, Messenger Rats, Inbred Strains Transcription, Genetic Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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