NDLI: Requirement for two DNA polymerases in the replication of simian virus 40 DNA in vitro.

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Requirement for two DNA polymerases in the replication of simian virus 40 DNA in vitro.

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Requirement for two DNA polymerases in the replication of simian virus 40 DNA in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weinberg, D. H. Kelly, T. J.
Description	Author Affiliation: Weinberg DH ( Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.);
Abstract	DNA polymerase alpha-primase has long been considered the primary, if not sole, replicative DNA polymerase in eukaryotic cells. However, recent experiments have provided indirect evidence that a second DNA polymerase may play a role in DNA replication. To identify cellular proteins necessary for DNA synthesis in mammalian cells, we have been studying the cell-free system developed for the replication of simian virus 40 DNA. In this report, we present direct evidence that a second DNA polymerase is required in addition to DNA polymerase alpha-primase complex to obtain efficient replication of simian virus 40 origin-containing DNA. This DNA polymerase activity is not affected by monoclonal antibodies that inhibit the activity of DNA polymerase alpha and is relatively resistant to the inhibitor [N2-(p-n-butylphenyl)-9-(2-deoxy-beta-D-ribofuranosyl)guanine 5'-triphosphate]. Moreover, the activity of the polymerase is highly dependent upon the accessory protein, proliferating-cell nuclear antigen. These characteristics are consistent with the hypothesis that this second DNA polymerase is DNA polymerase delta.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Replication DNA-Directed DNA Polymerase Metabolism RNA Nucleotidyltransferases Simian Virus 40 Genetics Antibodies, Monoclonal Chromatography, Ion Exchange DNA Polymerase III DNA Primase Isolation & Purification Deoxyguanine Nucleotides Pharmacology HeLa Cells Enzymology Kinetics Nuclear Proteins Nucleic Acid Synthesis Inhibitors Proliferating Cell Nuclear Antigen Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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