NDLI: Isolation and characterization of a cDNA clone encoding avian skeletal muscle C-protein: an intracellular member of the immunoglobulin superfamily.

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Isolation and characterization of a cDNA clone encoding avian skeletal muscle C-protein: an intracellular member of the immunoglobulin superfamily.

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Isolation and characterization of a cDNA clone encoding avian skeletal muscle C-protein: an intracellular member of the immunoglobulin superfamily.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fischman, D. A. Einheber, S.
Description	Author Affiliation: Einheber S ( Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021.);
Abstract	C-protein is a thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A bands. Its function is unknown. To improve our understanding of its primary structure, we undertook the molecular cloning of C-protein mRNA. We describe the isolation and characterization of a cDNA clone, lambda C-86, that encodes approximately 80% of the fast isoform of C-protein in the chicken. Sequence analysis of the insert revealed that C-protein, although an intracellular, nonmembrane-associated protein, is a member of the immunoglobulin superfamily. Like several cell surface adhesion molecules that belong to this superfamily, C-protein contains sequence motifs that resemble immunoglobulin domains and fibronectin type III repeats. Computer searches using the C-protein sequence also lead to the identification of related domains in chicken smooth muscle myosin light chain kinase that have not been reported previously.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Immunoglobulin Multigene Family Muscle Proteins Genetics Muscles Metabolism Amino Acid Sequence Animals Blotting, Northern Carrier Proteins Cloning, Molecular DNA Isolation & Purification Gene Library Molecular Sequence Data Protein Biosynthesis RNA, Messenger Sequence Homology, Nucleic Acid Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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