NDLI: Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

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Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

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Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koseki, H. Moriwaki, K. Taniguchi, M. Imai, K. Sado, T. Nakayama, F.
Description	Author Affiliation: Koseki H ( Division of Molecular Immunology, School of Medicine, Chiba University, Japan.);
Abstract	Nucleotide sequences of VJ (variable-joining) junctional regions of V14+ alpha-chain T-cell receptor genes show that most V alpha 14+ T cells use one alpha chain (V alpha 14J alpha 281 with a one-nucleotide N region, which is frequently used in keyhole limpet hemocyanin-specific suppressor T-cell hybridomas) in unprimed mice. Moreover, the frequency of this alpha-chain expression was greater than 1.5% of the total alpha chains found in laboratory strains, including B10 congenic mice. This is about 10(4) times higher than was expected. The V14J281 alpha-chain expression was relatively low but was significant in CD4+/CD8+ immature thymocytes and became quite high in mature single-positive T cells, implying that this alpha chain is selected during T-cell maturation. V14J281 expression increased with time after birth and reached a maximum at around 5 weeks of age. The ligand seems to be a self molecule and to be present in laboratory strains but to be absent in a wild mouse, Mus musculus molossinus, because bone marrow chimeras clearly showed that bone marrow cells derived from Mus musculus molossinus negative for this alpha chain raised V14J281-positive T cells in a C57BL/6 environment. The above results suggest that there are some selection mechanisms for this cell type other than those for conventional alpha beta T cells and also that the homogenous VJ junction of the V14J281 alpha chain plays a pivotal role in the selection of the T cell and its ligand reactivity.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Antigen, T-Cell Genetics T-Lymphocytes Immunology Animals Animals, Newborn Mice Mice, Inbred C57BL Mice, Inbred Strains Molecular Sequence Data Oligonucleotide Probes Polymerase Chain Reaction Ribonucleases Spleen Cytology Thymus Gland Transcription, Genetic Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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