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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Carr, K. D. Richard-foy, H. |
| Description | Author Affiliation: Carr KD ( Unité de Recherches sur les Communications Hormonales, Institut National de la Santé et de la Recherche Médicale U-33, Hôpital du Kremlin Bicêtre, France.); |
| Abstract | Transcriptional activation by steroid hormones is often associated with the appearance of a DNase I hypersensitive site resulting from a local alteration of the nucleoprotein structure of the promoter. For the mouse mammary tumor virus long terminal repeat, a viral promoter under glucocorticoid control, a model has been proposed: the appearance of the hormonodependent DNase I hypersensitive site reflects the displacement of a single precisely positioned nucleosome associated with the glucocorticoid responsive elements. To determine if such a mechanism is of general relevance in transcriptional activation by steroid hormones, we have investigated the nucleosomal organization of the rat tyrosine aminotransferase promoter over a 1-kilobase region that contains the glucocorticoid regulatory target. This region displays a hormonodependent DNase I hypersensitive site. In the absence of hormone, micrococcal nuclease digestion of nuclei demonstrates the presence of positioned nucleosomes, with cutting sites centered around positions -3080, -2900, -2700, -2800, -2255, and -2040. Treatment of the cells with dexamethasone induces a disruption of the chromatin structure over a relatively short stretch of DNA (approximately positions -2400 to -2650) that overlaps two nucleosomes. These observations suggest a strong similarity in the role of chromatin structure in glucocorticoid-dependent transcriptional activation of mouse mammary tumor virus and tyrosine aminotransferase promoters. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 23 |
| Volume Number | 87 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1990-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dexamethasone Pharmacology Liver Neoplasms, Experimental Enzymology Nucleosomes Metabolism Promoter Regions, Genetic Tyrosine Transaminase Genetics Animals Cell Line Deoxyribonuclease I Genes Drug Effects Micrococcal Nuclease Molecular Sequence Data Nucleotide Mapping Regulatory Sequences, Nucleic Acid Restriction Mapping Transcription, Genetic Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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