NDLI: Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

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Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

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Two-dimensional life?

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Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tirone, F. Bradbury, A. Possenti, R. Shooter, E. M.
Description	Author Affiliation: Bradbury A ( Istituto di Neurobiologia, Consiglio Nazionale delle Ricerche, Rome, Italy.);
Abstract	PC3 is an immediate early gene induced by nerve growth factor in PC12 cells, a cell line derived from a tumor of the adrenal medulla that undergoes neuronal differentiation in the presence of nerve growth factor. This induction is independent of new protein synthesis as it can occur in the presence of cycloheximide. PC3 is also induced with similar kinetics, but at lower levels, by membrane depolarization (both in vivo and in vitro) and epidermal growth factor. It is induced at much lower levels by fibroblast growth factor and interleukin 6. In vivo it is found expressed in tissues, such as brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating. The deduced protein sequence from the cDNA indicates the presence of a signal peptide, suggesting that PC3 is secreted.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adrenal Gland Neoplasms Genetics Immediate-Early Proteins Membrane Potentials Drug Effects Neoplasm Proteins Nerve Growth Factors Pharmacology Nerve Tissue Proteins Pheochromocytoma Amino Acid Sequence Animals Bucladesine Cloning, Molecular DNA Epidermal Growth Factor Fibroblast Growth Factors Gene Expression Secretion Interleukin-6 Molecular Sequence Data Pentylenetetrazole Potassium Chloride RNA, Messenger Restriction Mapping Tetradecanoylphorbol Acetate Tissue Distribution Tumor Suppressor Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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