NDLI: Role of glutathione in an animal model of myoglobinuric acute renal failure.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1991 Volume: 88 Issue: 24

Year: 1991 Volume: 88 Issue: 23

Year: 1991 Volume: 88 Issue: 22

Year: 1991 Volume: 88 Issue: 21

Geonium 'K' experiment using spin dependency of cyclotron frequency supports g data of earlier geonium 'S' work.

Phosphate-starvation response in plant cells: de novo synthesis and degradation of acid phosphatases.

Magnetospheric imaging with low-energy neutral atoms.

Early tertiary elephant-shrews from Egypt and the origin of the Macroscelidea.

Spectral kinetics of glutamate-1-semialdehyde aminomutase of Synechococcus.

Analysis of the energy of the first four excited states of the ground-state rotational bands of the even-even nuclei from 6C8 to 56Ba90 with the model of a single cluster of nucleons revolving about a sphere.

Tensor species and symmetric functions.

Direct assignment of vitamin K1 as the secondary acceptor A1 in photosystem I.

Isolation of temperature-sensitive mutations of the tyrosine kinase receptor sevenless (sev) in Drosophila and their use in determining its time of action.

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

Brain and heart sodium channel subtype mRNA expression in rat cerebral cortex.

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Quantitative assay for morphogenesis indicates the role of extracellular matrix components and G proteins.

Alternative splicing and genomic structure of the Wilms tumor gene WT1.

A peptide mimetic of calcium.

Deactivation kinetics of the transduction cascade of vision.

Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response.

Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.

Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA.

PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.

Acetyl-CoA carboxylase from Escherichia coli: gene organization and nucleotide sequence of the biotin carboxylase subunit.

Identification of markers linked to disease-resistance genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions by using segregating populations.

Lymphoid organs function as major reservoirs for human immunodeficiency virus.

Detection of vitronectin mRNA in tissues and cells of the mouse.

Structure of the human hexabrachion (tenascin) gene.

Nonresponsiveness to an immunodominant Epstein-Barr virus-encoded cytotoxic T-lymphocyte epitope in nuclear antigen 3A: implications for vaccine strategies.

Limitations in plasticity of the T-cell receptor repertoire.

Cross-reactions and specificities of monoclonal antibodies against myelin basic protein and against the synthetic copolymer 1.

Identification of a continuous and cross-reacting epitope for Plasmodium falciparum transmission-blocking immunity.

Inhibition by interferon of herpes simplex virus type 1-activated transcription of tat-defective provirus.

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts.

DNA.RNA helicase activity of RAD3 protein of Saccharomyces cerevisiae.

Reverse transcriptase encoded by a retrotransposon from the trypanosomatid Crithidia fasciculata.

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.

Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium.

Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors.

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

DnaK as a thermometer: threonine-199 is site of autophosphorylation and is critical for ATPase activity.

Fc receptors for IgG (Fc gamma Rs) on human monocytes and macrophages are not infectivity receptors for human immunodeficiency virus type 1 (HIV-1): studies using bispecific antibodies to target HIV-1 to various myeloid cell surface molecules, including the Fc gamma R.

Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2'-O-methyl oligoribonucleotides.

Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

Noninvasive detection of changes in membrane potential in cultured neurons by light scattering.

FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction.

Specificity and stringency in DNA triplex formation.

Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants.

Mechanism of activation of sensory rhodopsin I: evidence for a steric trigger.

Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence.

Growth in high serum concentrations leads to rapid deadaptation of cells previously adapted to growth in an extremely low concentration of serum.

Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.

GCR1 of Saccharomyces cerevisiae encodes a DNA binding protein whose binding is abolished by mutations in the CTTCC sequence motif.

Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.

Identification of an allatostatin from the tobacco hornworm Manduca sexta.

Subunit interactions change the heme active-site geometry in p-cresol methylhydroxylase.

Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution.

Do interhelical side chain-backbone hydrogen bonds participate in formation of leucine zipper coiled coils?

Transformation of Tetrahymena to cycloheximide resistance with a ribosomal protein gene through sequence replacement.

Gene targeting in Chinese hamster ovary cells is conservative.

Invertebrate cytokines: tunicate cell proliferation stimulated by an interleukin 1-like molecule.

A genomic scanning method for higher organisms using restriction sites as landmarks.

Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes.

Sequence of general transcription factor TFIIB and relationships to other initiation factors.

The molecular structure of wild-type and a mutant Fis protein: relationship between mutational changes and recombinational enhancer function or DNA binding.

Characterization and mapping of human genes encoding zinc finger proteins.

Mediation of lung metastasis of murine melanomas by a lung-specific endothelial cell adhesion molecule.

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

Acetylaminofluorene and aminofluorene adducts inhibit in vitro transcription of a Xenopus 5S RNA gene only when located on the coding strand.

Membrane topology analysis of Escherichia coli mannitol permease by using a nested-deletion method to create mtlA-phoA fusions.

Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex.

Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development.

cDNA selection: efficient PCR approach for the selection of cDNAs encoded in large chromosomal DNA fragments.

Direct selection: a method for the isolation of cDNAs encoded by large genomic regions.

Mosaic expression of a tyrosinase fusion gene in albino mice yields a heritable striped coat color pattern in transgenic homozygotes.

Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene.

A neural network model of sensoritopic maps with predictive short-term memory properties.

Identification of the neurofibromatosis type 1 gene product.

Rescue of synthetic analogs of respiratory syncytial virus genomic RNA and effect of truncations and mutations on the expression of a foreign reporter gene.

Quantitation of prenylcysteines by a selective cleavage reaction.

Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport.

Positive DNA supercoiling generates a chromatin conformation characteristic of highly active genes.

The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 3' thymine-to-cytosine transitions in Escherichia coli.

Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning.

Human alpha-L-iduronidase: cDNA isolation and expression.

Identification and functional activity of prolactin receptors in thymic epithelial cells.

On the use of combinatorial antibody libraries to clone the 'fossil record' of an individual's immune response.

Further characterization of the receptor-binding region of the thyroid-stimulating hormone alpha subunit: a comprehensive synthetic peptide study of the alpha-subunit 26-46 sequence.

Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.

Dual modulation of renal ATP-sensitive K+ channel by protein kinases A and C.

Direct binding of a synthetic multichain polypeptide to class II major histocompatibility complex molecules on antigen-presenting cells and stimulation of a specific T-cell line require processing of the polypeptide.

Transforming growth factor alpha contributes to the mechanism by which hypothalamic injury induces precocious puberty.

A search for protein structural changes accompanying the contractile interaction.

A 30-residue-long 'export initiation domain' adjacent to the signal sequence is critical for protein translocation across the inner membrane of Escherichia coli.

DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.

Expression of a swine class II gene in murine bone marrow hematopoietic cells by retroviral-mediated gene transfer.

Dietary protein restriction rapidly reduces transforming growth factor beta 1 expression in experimental glomerulonephritis.

Polydnavirus DNA is integrated in the DNA of its parasitoid wasp host.

mRNA leader length and initiation codon context determine alternative AUG selection for the yeast gene MOD5.

Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

Ultrafast spectroscopy of the visual pigment rhodopsin.

DS28-6, a temperature-sensitive mutant of Chinese hamster ovary cells, expresses key phenotypic changes associated with brefeldin A treatment.

Excess nonsynonymous substitution of shared polymorphic sites among self-incompatibility alleles of Solanaceae.

Role of glutathione in an animal model of myoglobinuric acute renal failure.

Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies.

Inverse changes in erythroid cell volume and number regulate the hematocrit in newborn genetically hypertensive rats.

Genetic variants of serum albumin in Americans and Japanese.

A determinant of disease symptom severity is located in the 3'-terminal noncoding region of the RNA of a plant virus.

The path of calcium in cytosolic calcium oscillations: a unifying hypothesis.

Hypoxia induces endothelial cell synthesis of membrane-associated proteins.

The in vitro response of phenotypically defined mouse stem cells and myeloerythroid progenitors to single or multiple growth factors.

Year: 1991 Volume: 88 Issue: 20

Year: 1991 Volume: 88 Issue: 19

Year: 1991 Volume: 88 Issue: 18

Year: 1991 Volume: 88 Issue: 17

Year: 1991 Volume: 88 Issue: 16

Year: 1991 Volume: 88 Issue: 15

Year: 1991 Volume: 88 Issue: 14

Year: 1991 Volume: 88 Issue: 13

Year: 1991 Volume: 88 Issue: 12

Year: 1991 Volume: 88 Issue: 11

Year: 1991 Volume: 88 Issue: 10

Year: 1991 Volume: 88 Issue: 9

Year: 1991 Volume: 88 Issue: 8

Year: 1991 Volume: 88 Issue: 7

Year: 1991 Volume: 88 Issue: 6

Year: 1991 Volume: 88 Issue: 5

Year: 1991 Volume: 88 Issue: 4

Year: 1991 Volume: 88 Issue: 3

Year: 1991 Volume: 88 Issue: 2

Year: 1991 Volume: 88 Issue: 1

Two-dimensional life?

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Role of glutathione in an animal model of myoglobinuric acute renal failure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shah, S. V. Walker, P. D. Abul-ezz, S. R.
Description	Author Affiliation: Abul-Ezz SR ( Tulane University School of Medicine, Department of Medicine, New Orleans, LA 70112.);
Abstract	In a previous study we have shown a role for reactive oxygen metabolites in glycerol-induced acute renal failure, a well-established model for myoglobinuric acute renal failure. In the present study we examined the role of glutathione in this model of acute renal failure. Administration of 50% (vol/vol) glycerol at a dose of 10 ml/kg of body weight to rats intramuscularly resulted in significant renal failure associated with depletion of total kidney glutathione (GSH) from 2.6 +/- 0.1 mumol/g (mean +/- SEM control level) to 1.7 +/- 0.1 mumol/g after 6 hr (P less than 0.001). If GSH were important in glycerol-induced acute renal failure, one would anticipate that exogenously administered GSH should afford protection, while injury should be potentiated if endogenous GSH is depleted. We examined the effect of i.p. administration of L-buthionine-(S,R)-sulfoximine (BSO) at 2 mmol/kg (which results in depletion of kidney GSH) and the effect of increasing renal GSH by i.v. administration of reduced GSH (2 mmol/kg every 3 hr) on kidney function in glycerol-treated rats. Glycerol-injected rats treated with BSO showed significantly worse renal failure than did rats given glycerol alone, while administration of GSH resulted in significant amelioration of glycerol-induced acute renal failure [glycerol treatment alone, blood urea nitrogen (BUN) = 96 +/- 10 and creatinine = 2.5 +/- 0.4 mg/dl; BSO + glycerol treatment, BUN = 123 +/- 7 and creatinine = 3.5 +/- 0.1 mg/dl (n = 9, P less than 0.05); GSH + glycerol treatment, BUN = 78 +/- 10 and creatinine = 1.25 +/- 0.2 mg/dl (n = 8, P less than 0.05)]. In separate experiments 1,3-bis(chloroethyl)-1-nitrosourea (BCNU) [which interferes with the enzyme GSH reductase and prevents recycling of oxidized GSH (GSSG) into GSH] resulted in worsening of glycerol-induced acute renal failure similar to that produced by BSO. These functional differences between GSH-depleted and GSH-repleted rats were further substantiated by significant histological differences in tubular injury. Taken together, these results provide evidence for an important role of GSH in glycerol-induced acute renal failure.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Acute Kidney Injury Physiopathology Glutathione Physiology Kidney Pathology Animals Blood Urea Nitrogen Creatinine Blood Glycerol Toxicity Myoglobinuria Necrosis Rats, Inbred Strains Vacuoles Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in