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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hassan, H. M. Sun, H. C. |
| Description | Author Affiliation: Hassan HM ( Department of Biochemistry, North Carolina State University, Raleigh 27695-7622.); |
| Abstract | Transcriptional regulation of the sodA gene, encoding the manganese superoxide dismutase (superoxide: superoxide oxidoreductase, EC 1.15.1.1) of Escherichia coli, was studied by monitoring expression of sodA-lacZ in different genetic backgrounds and under different growth conditions. Mutations in the fnr gene were found to affect aerobic and anaerobic expression of sodA-lacZ. Potential Fnr-binding sites were identified in the promoter region of sodA. Strains harboring simultaneous mutations in arcA/B and fur expressed sodA-lacZ under anaerobic growth conditions but were still inducible by iron chelators. However, in the triple mutants (fnr fur arcA/B) sodA-lacZ was fully expressed under anaerobiosis and was not further induced by the presence of 2,2'-dipyridyl, nitrate, or oxidants. On the other hand, aerobic expression of sodA-lacZ from a Fur-strain was approximately 3.8-fold higher than that from the wild-type strain but was diminished by introducing mutations in fnr or arcA/B. In conclusion, Fnr, Arc, and Fur act as anaerobic repressors of sodA. Furthermore, the regulation of sodA by Fur (ferric uptake regulation protein), Arc (aerobic respiratory control), and Fnr (fumarate nitrate reduction/regulator of anaerobic respiration) is independent of the superoxide response regulon SoxRS. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 89 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1992-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bacterial Proteins Genetics Escherichia Coli Proteins Escherichia Coli Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Genes, Bacterial Iron-Sulfur Proteins Isoenzymes Manganese Metabolism Recombinant Proteins Biosynthesis Repressor Proteins Superoxide Dismutase Transcription Factors Viral Proteins 2,2'-Dipyridyl Pharmacology Aerobiosis Anaerobiosis Drug Effects Enzymology Genotype Molecular Sequence Data Nitrates Oligodeoxyribonucleotides Oxidants Paraquat Recombinant Fusion Proteins Viral Regulatory And Accessory Proteins Beta-Galactosidase Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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