NDLI: Macromolecular assemblage in the design of a synthetic AIDS vaccine.

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Macromolecular assemblage in the design of a synthetic AIDS vaccine.

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Macromolecular assemblage in the design of a synthetic AIDS vaccine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, W. Tam, J. P. Defoort, J. P. Nardelli, B. Ho, D. D.
Description	Author Affiliation: Defoort JP ( Rockefeller University, New York, NY 10021.);
Abstract	We describe a peptide vaccine model based on the mimicry of surface coat protein of a pathogen. This model used a macromolecular assemblage approach to amplify peptide antigens in liposomes or micelles. The key components of the model consisted of an oligomeric lysine scaffolding to amplify peptide antigens covalently 4-fold and a lipophilic membrane-anchoring group to further amplify noncovalently the antigens many-fold in liposomal or micellar form. A peptide antigen derived from the third variable domain of glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1), consisting of neutralizing, T-helper, and T-cytotoxic epitopes, was used in a macromolecular assemblage model (HIV-1 linear peptide amino acid sequence 308-331 in a tetravalent multiple antigen peptide system linked to tripalmitoyl-S-glycerylcysteine). The latter complex, in liposome or micelle, was used to immunize mice and guinea pigs without any adjuvant and found to induce gp120-specific antibodies that neutralize virus infectivity in vitro, elicit cytokine production, and prime CD8+ cytotoxic T lymphocytes in vivo. Our results show that the macromolecular assemblage approach bears immunological mimicry of the gp120 of HIV virus and may lead to useful vaccines against HIV infection.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	AIDS Vaccines Immunology Acquired Immunodeficiency Syndrome Prevention & Control HIV Antibodies HIV Envelope Protein Gp120 Amino Acid Sequence Animals B-Lymphocytes CD4-Positive T-Lymphocytes HIV Antigens Interleukin-2 Biosynthesis Mice Molecular Sequence Data Neutralization Tests T-Lymphocytes, Cytotoxic Vaccines, Synthetic Chemistry Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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