NDLI: Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2.

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Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jeggo, P. A. Hafezparast, M. Broughton, B. C. Kaur, G. P. Zdzienicka, M. Z. Athwal, R. S. Thompson, A. F.
Description	Author Affiliation: Jeggo PA ( Medical Research Council Cell Mutation Unit, Sussex University, Brighton, United Kingdom.);
Abstract	Complementation of the repair defect in hamster xrs mutants has been achieved by transfer of human chromosome 2 using the method of microcell-mediated chromosome transfer. The xrs mutants belong to ionizing radiation complementation group 5, are highly sensitive to ionizing radiation, and have an impaired ability to rejoin radiation-induced DNA double-strand breaks. Both phenotypes were corrected by chromosome 2, although the correction of radiation sensitivity was only partial. Complementation was achieved in two members of this complementation group, xrs6 and XR-V15B, derived independently from the CHO and V79 cell lines, respectively. The presence of human chromosome 2 in complemented clones was examined cytogenetically and by PCR analysis with primers directed at a human-specific long interspersed repetitive sequence or chromosome 2-specific genes. Complementation was observed in 25/27 hybrids, one of which contained only the q arm of chromosome 2. The two noncomplementing hybrids were missing segments of chromosome 2. The use of a back-selection system enabled the isolation of clones that had lost the human chromosome and these regained radiation sensitivity. Transfer of several other human chromosomes did not result in complementation of the repair defect in XR-V15B. These data show that the gene defective in xrs cells, XRCC5, which is involved in double-strand break rejoining, is located on human chromosome 2q.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomes, Human, Pair 2 DNA Repair Chromosome Banding Chromosome Mapping Ultrastructure Genetic Complementation Test Polymerase Chain Reaction Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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