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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Torti, M. Lapetina, E. G. |
| Description | Author Affiliation: Torti M ( Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC 27709.); |
| Abstract | Thrombin activates phospholipase C in human platelets, but the specific isoenzymes activated and the signal pathway used are unknown. Using specific antibodies, we found that phospholipase C-gamma 1 and the p21ras GTPase-activating protein, rasGAP, are present in human platelets. Furthermore, phospholipase C-gamma 1 was detectable, based on enzyme activity and Western blot analysis, in immunoprecipitates of rasGAP, suggesting that these two proteins form tight complexes. The pool of phospholipase C-gamma 1 associated with rasGAP was phosphorylated but not through tyrosine phosphorylation. Although thrombin stimulation had no effect on the level of phosphorylation of phospholipase C-gamma 1 and only slightly increased the tyrosine phosphorylation of rasGAP, the agonist induced the association of rasGAP with rap1B, as indicated by the appearance of rap1B on a Western blot of rasGAP immunoprecipitates. Our results suggest the formation of a signaling complex involving rasGAP, phospholipase C-gamma 1, and rap1B that might be important in the cascade leading to platelet activation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 89 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1992-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Blood Platelets Enzymology GTP-Binding Proteins Metabolism Isoenzymes Blood Phosphoric Diester Hydrolases Proteins Drug Effects Blood Proteins Isolation & Purification Electrophoresis, Polyacrylamide Gel GTPase-Activating Proteins Biosynthesis Kinetics Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Diacylglycerol-Lyase Phosphatidylinositols Phosphoproteins Phosphorylation Protein Binding Thrombin Pharmacology Rap GTP-Binding Proteins Ras GTPase-Activating Proteins Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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