NDLI: Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1992 Volume: 89 Issue: 24

Apparent nonlinearity of the redshift-distance relation in infrared astronomical satellite galaxy samples.

Floral isolation between ornithophilous and sphingophilous species of Ipomopsis and Aquilegia.

Resource choice in Cuscuta europaea.

Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord.

Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.

Regulation of mouse gamete interaction by a sperm tyrosine kinase.

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.

Cell cycle-dependent changes in the organization of an intermediate filament-associated protein: correlation with phosphorylation by p34cdc2.

Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus.

Nitric oxide synthase in macula densa regulates glomerular capillary pressure.

Expression cloning of a human dual-specificity phosphatase.

Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells.

Nitric oxide: linking space and time in the brain.

Potassium transport into plant vacuoles energized directly by a proton-pumping inorganic pyrophosphatase.

Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein.

Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression.

RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs.

Tumor necrosis factor alpha stimulates expression of adenovirus early region 3 proteins: implications for viral persistence.

Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response.

Cantharidin-binding protein: identification as protein phosphatase 2A.

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

Interferon gamma rapidly induces in human monocytes a DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high-affinity Fc gamma receptor.

Odor-induced phosphorylation of olfactory cilia proteins.

The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 89 Issue: 24)

Dopamine enhances both electrotonic coupling and chemical excitatory postsynaptic potentials at mixed synapses.

Photoreceptors of mouse retinas possess D4 receptors coupled to adenylate cyclase.

Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation.

Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.

Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle.

The importance of being flexible.

Molecular mimicry of hepatitis B surface antigen by an anti-idiotype-derived synthetic peptide.

Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker.

Recycling and phosphorylation of eukaryotic initiation factor 2 on 60S subunits of 80S initiation complexes and polysomes.

Activity of the Hsp70 chaperone complex--DnaK, DnaJ, and GrpE--in initiating phage lambda DNA replication by sequestering and releasing lambda P protein.

Population genetics in the forensic DNA debate.

Androgen-specific gene activation via a consensus glucocorticoid response element is determined by interaction with nonreceptor factors.

Transcription factor IIA is inactivated during terminal differentiation of avian erythroid cells.

The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene.

A different sort of Mott cell.

Ascaris hemoglobin gene: plant-like structure reflects the ancestral globin gene.

Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.

Circadian oscillations in period gene mRNA levels are transcriptionally regulated.

Insulin-like growth factor II stimulates motor nerve regeneration.

Carbonic anhydrase in the membrane of the endoplasmic reticulum of male rat liver.

Honeybee colony integration: worker-worker interactions mediate hormonally regulated plasticity in division of labor.

Expression of hepatitis B surface antigen in transgenic plants.

Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding.

Modulation of synaptic gain by light.

Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span.

Domain motions in phosphoglycerate kinase: determination of interdomain distance distributions by site-specific labeling and time-resolved fluorescence energy transfer.

Amplifiable messenger RNA.

Molecular cloning of a gene encoding a seed-specific protein with nutritionally balanced amino acid composition from Amaranthus.

Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove.

Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures.

Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants.

Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations.

Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition.

Calcium ions are involved in Escherichia coli chemotaxis.

Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau).

Characterization of the Ca(2+)-triggered conformational transition in troponin C.

Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.

A nuclear localization signal and the C-terminal omega sequence in the Agrobacterium tumefaciens VirD2 endonuclease are important for tumor formation.

A human interleukin 3 analog with increased biological and binding activities.

Axon substitution in the reorganization of developing neural connections.

Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro.

Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat.

1H NMR studies on the catalytic subunit of aspartate transcarbamoylase.

Major histocompatibility complex class II genes of zebrafish.

Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins.

A 69-kDa RNA-binding protein from Xenopus oocytes recognizes a common motif in two vegetally localized maternal mRNAs.

Relationships between orientation-preference pinwheels, cytochrome oxidase blobs, and ocular-dominance columns in primate striate cortex.

Deformation of DNA during site-specific recombination of bacteriophage lambda: replacement of IHF protein by HU protein or sequence-directed bends.

Primary structure of an archaebacterial transducer, a methyl-accepting protein associated with sensory rhodopsin I.

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

DNA strand-specific repair of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase gene.

Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane.

Gene-culture coevolution: toward a general theory of vertical transmission.

Resistance to host antimicrobial peptides is necessary for Salmonella virulence.

Formation of guide RNA/messenger RNA chimeric molecules in vitro, the initial step of RNA editing, is dependent on an anchor sequence.

Insertional mutagenesis of hydrophilic domains in the lactose permease of Escherichia coli.

Induction of expression of monocyte interleukin 1 by Hageman factor (factor XII).

Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors.

The alternative sigma factor katF (rpoS) regulates Salmonella virulence.

Involvement of cytochrome P450 in host-plant utilization by Sonoran Desert Drosophila.

High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C.

Human immunodeficiency virus gp120 binding C'C' ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules.

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

Adhesion and incorporation of lacZ-transduced endothelial cells into the intact capillary wall in the rat.

Spectral enhancement of proteins: biological incorporation and fluorescence characterization of 5-hydroxytryptophan in bacteriophage lambda cI repressor.

Wild-type p53 binds to the TATA-binding protein and represses transcription.

Site-specific RNA cleavage generates the 3' end of a poxvirus late mRNA.

Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes.

Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications.

Distinct promoters direct neuronal and nonneuronal expression of rat aromatic L-amino acid decarboxylase.

Translocation of a folded protein across the outer membrane in Escherichia coli.

The Saccharomyces cerevisiae ARG4 initiator of meiotic gene conversion and its associated double-strand DNA breaks can be inhibited by transcriptional interference.

Chi sequence protects against RecBCD degradation of DNA in vivo.

Organization of the human skeletal myosin heavy chain gene cluster.

Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.

Sequence-structure matching in globular proteins: application to supersecondary and tertiary structure determination.

Patterns of spatiotemporal organization in an 'ambiquitous' enzyme model.

Repair of DNA damaged by UV light and ionizing radiation by cell-free extracts prepared from Schizosaccharomyces pombe.

Empty and peptide-containing conformers of class I major histocompatibility complex molecules expressed in Drosophila melanogaster cells.

Genomic structure of the human caldesmon gene.

Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis.

Costs of deception: cheaters are punished in rhesus monkeys (Macaca mulatta).

Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo.

Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.

High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences.

High expression of human beta S- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia.

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

Correlation analysis of amino acid usage in protein classes.

Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss.

Approach to a retrovirus vaccine: immunization of mice against Friend virus disease with a replication-defective Friend murine leukemia virus.

'Possible involvement of the long terminal repeat of transposable element 17.6 in regulating expression of an insecticide resistance-associated P450 gene in Drosophila.'.

Year: 1992 Volume: 89 Issue: 23

Year: 1992 Volume: 89 Issue: 22

Year: 1992 Volume: 89 Issue: 21

Year: 1992 Volume: 89 Issue: 20

Year: 1992 Volume: 89 Issue: 19

Year: 1992 Volume: 89 Issue: 18

Year: 1992 Volume: 89 Issue: 17

Year: 1992 Volume: 89 Issue: 16

Year: 1992 Volume: 89 Issue: 15

Year: 1992 Volume: 89 Issue: 14

Year: 1992 Volume: 89 Issue: 13

Year: 1992 Volume: 89 Issue: 12

Year: 1992 Volume: 89 Issue: 11

Year: 1992 Volume: 89 Issue: 10

Year: 1992 Volume: 89 Issue: 9

Year: 1992 Volume: 89 Issue: 8

Year: 1992 Volume: 89 Issue: 7

Year: 1992 Volume: 89 Issue: 6

Year: 1992 Volume: 89 Issue: 5

Year: 1992 Volume: 89 Issue: 4

Year: 1992 Volume: 89 Issue: 3

Year: 1992 Volume: 89 Issue: 2

Year: 1992 Volume: 89 Issue: 1

On the nature of global classification.

Theory of hydrophobicity: transient cavities in molecular liquids.

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cheng, N. Lowy, D. R. Booy, F. Kirnbauer, R. Schiller, J. T.
Description	Author Affiliation: Kirnbauer R ( Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.);
Abstract	Infection by certain human papillomavirus types is regarded as the major risk factor in the development of cervical cancer, one of the most common cancers of women worldwide. Analysis of the immunogenic and structural features of papillomavirus virions has been hampered by the inability to efficiently propagate the viruses in cultured cells. For instance, it has not been established whether the major capsid protein L1 alone is sufficient for virus particle assembly. In addition, it is not known whether L1, L2 (the minor capsid protein), or both present the immunodominant epitopes required for induction of high-titer neutralizing antibodies. We have expressed the L1 major capsid proteins of bovine papillomavirus type 1 and human papillomavirus type 16 in insect cells via a baculovirus vector and analyzed their conformation and immunogenicity. The L1 proteins were expressed at high levels and assembled into structures that closely resembled papillomavirus virions. The self-assembled bovine papillomavirus L1, in contrast to L1 extracted from recombinant bacteria or denatured virions, also mimicked intact bovine papillomavirus virions in being able to induce high-titer neutralizing rabbit antisera. These results indicate that L1 protein has the intrinsic capacity to assemble into empty capsid-like structures whose immunogenicity is similar to infectious virions. This type of L1 preparation might be considered as a candidate for a serological test to measure antibodies to conformational virion epitopes and for a vaccine to prevent papillomavirus infection.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Viral Metabolism Capsid Proteins Capsid Oncogene Proteins, Viral Papillomaviridae Immunology Animals Antibodies, Viral Macromolecular Substances Microscopy, Electron Molecular Sequence Data Morphogenesis Neutralization Tests Oligodeoxyribonucleotides Chemistry Ultrastructure Rabbits Recombinant Proteins Vaccines, Synthetic Viral Vaccines Virus Replication Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in