NDLI: Systemic immunological effects of cytokine genes injected into skeletal muscle.

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Systemic immunological effects of cytokine genes injected into skeletal muscle.

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Systemic immunological effects of cytokine genes injected into skeletal muscle.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Parr, T. B. Baird, S. M. Lotz, M. Kipps, T. J. Watanabe, A. Raz, E. Eisenberg, R. A. Carson, D. A.
Description	Author Affiliation: Raz E ( Department of Medicine, University of California, San Diego, La Jolla 92093-0663.);
Abstract	Somatic gene therapy is an interesting approach for the delivery of cytokines for prolonged periods. The present experiments show that direct injections into mouse skeletal muscle of cDNA expression vectors encoding interleukin 2 (IL-2), IL-4, or type beta 1 transforming growth factor (TGF-beta 1) induce biological effects characteristic of these cytokines in vivo. Mice injected intramuscularly with a vector encoding IL-2 had enhanced humoral and cellular immune responses to an exogenous antigen, transferrin, that was delivered at a separate site. These IL-2 effects were abolished by coadministration of a vector directing synthesis of TGF-beta 1. The TGF-beta 1 vector by itself depressed the anti-transferrin antibody response and caused an 8-fold increase in plasma TGF-beta 1 activity. The TGF-beta 1 plasmid injection did not cause muscle infiltration with monocytes or neutrophils and there was no evidence for fibrotic changes. Muscle injection with a cDNA encoding IL-4 selectively increased IgG1 levels but did not alter the cellular immune response to transferrin. In lupus-prone mice (MRL/lpr/lpr), injection with IL-2 expression vectors increased and TGF-beta 1 vectors decreased auto-antibodies to chromatin. These results demonstrate that intramuscular injection of cytokine genes, in the absence of infectious viral vectors, can regulate humoral and cellular immune responses in vivo.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytokines Genetics Muscles Physiology Transfection Animals Antibody Formation Autoantibodies Biosynthesis Gene Expression Hypersensitivity, Delayed Immunology Immunoglobulin G Metabolism Injections, Intramuscular Lymphoproliferative Disorders Mice Mice, Inbred BALB C Mice, Mutant Strains Transforming Growth Factor Beta Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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