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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Scharfmann, R. Polak, M. Verma, I. M. Potter, H. Dressler, D. Eisenbarth, G. Seilheimer, B. |
| Description | Author Affiliation: Polak M ( Department of Neurobiology, Harvard Medical School, Boston, MA 02115.); |
| Abstract | Nerve growth factor (NGF) is the best understood of a class of trophic proteins that are important for the survival of neurons and the elaboration of their characteristic processes. Here we demonstrate that RINm5F, a rat insulinoma cell line representing an early stage in pancreatic beta cell differentiation, expresses both the Trk and p75 NGF receptors and responds to NGF by extending neurite-like (neurofilament-containing) processes. NGF treatment of RINm5F cells also induces the expression of genes normally responsive to NGF in neurons, including the NGF-1A gene. Inasmuch as pancreatic beta cells arise from the embryonic endoderm, these results suggest that NGF may play a wider role during development than previously thought-a role not restricted to cells of neuroectodermal origin--and that endocrine and neuronal cells share a developmental pathway. The specific effect of NGF on an early pancreatic beta cell line also suggests that this neurotrophic factor might form the basis of a therapeutic treatment for some types of diabetes by inducing the proliferative differentiation of islet cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation Drug Effects Insulin Secretion Nerve Growth Factors Pharmacology Neurons Cytology Receptors, Nerve Growth Factor Biosynthesis Animals Blotting, Northern Insulinoma Intermediate Filaments Ultrastructure PC12 Cells Pancreatic Neoplasms RNA, Messenger Metabolism Genetics Tumor Cells, Cultured Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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