NDLI: Isoproterenol stimulates rapid extrusion of sodium from isolated smooth muscle cells.

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Isoproterenol stimulates rapid extrusion of sodium from isolated smooth muscle cells.

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Isoproterenol stimulates rapid extrusion of sodium from isolated smooth muscle cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moore, E. D. Fay, F. S.
Description	Author Affiliation: Moore ED ( Department of Physiology, University of Massachusetts Medical Center, Worcester 01605.);
Abstract	beta-Agonists cause an inhibition of contractility and a transient stimulation of Na+/K+ pumping in smooth muscle cells of the stomach from the toad Bufo marinus. To determine if the stimulation of Na+/K+ pumping causes changes in intracellular [Na+] ([Na+]i) that might link Na+ pump stimulation to decrease Ca2+ availability for contraction, [Na+]i was measured in these cells with SBFI, a Na(+)-sensitive fluorescent indicator. Basal [Na+]i was 12.8 +/- 4.2 mM (n = 32) and was uniform throughout the cell. In response to isoproterenol, [Na+]i decreased an average of 7.1 +/- 1.1 mM in 3 sec. Since this decrease in [Na+]i could be completely blocked by inhibition of the Na+ pump, or by blockade of the beta-receptor, [Na+]i reduction is the result of occupation of the beta-receptor by isoproterenol and subsequent stimulation of the Na+ pump. 8-Bromoadenosine 3',5'-cyclic monophosphate and forskolin mimicked the effect of isoproterenol, indicating that the sequence of events linking beta-receptor occupation to Na+ pump stimulation most likely includes activation of adenylate cyclase, production of cAMP, and stimulation of cAMP-dependent protein kinase. The decrease in [Na+]i is sufficiently large and fast that it is expected to stimulate turnover of the Na+/Ca2+ exchanger in the Ca2+ extrusion mode, thereby accounting for the observed linkage between stimulation of the Na+/K+ pump and inhibition of contractility in response to beta-adrenergic agonists.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Isoproterenol Pharmacology Muscle, Smooth Metabolism Sodium 8-Bromo Cyclic Adenosine Monophosphate Animals Benzofurans Bufo Marinus Carbachol Colforsin Ethers, Cyclic Fluorescent Dyes In Vitro Techniques Kinetics Microscopy, Fluorescence Cytology Drug Effects Ouabain Pindolol Potassium Stomach Time Factors Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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