NDLI: Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1993 Volume: 90 Issue: 24

Year: 1993 Volume: 90 Issue: 23

Year: 1993 Volume: 90 Issue: 22

Year: 1993 Volume: 90 Issue: 21

Year: 1993 Volume: 90 Issue: 20

Poincaré resonances and the limits of trajectory dynamics.

Ethylene induces de novo synthesis of chlorophyllase, a chlorophyll degrading enzyme, in Citrus fruit peel.

Rapid application and removal of second messengers to cyclic nucleotide-gated channels from olfactory epithelium.

Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin.

The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.

Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.

Neural BC1 RNA as an evolutionary marker: guinea pig remains a rodent.

The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes.

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

Concordant mitochondrial and nuclear DNA phylogenies for populations of the teleost fish Fundulus heteroclitus.

Residual free calcium is not responsible for facilitation of neurotransmitter release.

The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo.

Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.

Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.

Crosstalk between alpha/beta T cells and gamma/delta T cells in vivo: activation of alpha/beta T-cell responses after gamma/delta T-cell modulation with the monoclonal antibody GL3.

Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro.

Mutant DnaK chaperones cause ribosome assembly defects in Escherichia coli.

Changes in intra- or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance.

Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure.

The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein.

The boundaries of partially edited transcripts are not conserved in kinetoplastids: implications for the guide RNA model of editing.

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein.

Vitamin D-influenced gene expression via a ligand-independent, receptor-DNA complex intermediate.

Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.

Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1.

Chromosome walking on the TCL1 locus involved in T-cell neoplasia.

Cloning, sequence determination, and regulation of the ribonucleotide reductase subunits from Plasmodium falciparum: a target for antimalarial therapy.

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

A site required for termination of packaging of the phage lambda chromosome.

Transformation of Tetrahymena thermophila by microinjection of a foreign gene.

glh-1, a germ-line putative RNA helicase from Caenorhabditis, has four zinc fingers.

Regional expression and chromosomal localization of the delta opiate receptor gene.

Maize mitochondrial manganese superoxide dismutases are encoded by a differentially expressed multigene family.

Multiple nucleosome positioning with unique rotational setting for the Saccharomyces cerevisiae 5S rRNA gene in vitro and in vivo.

Recognition of specific DNA sequences by the c-myb protooncogene product: role of three repeat units in the DNA-binding domain.

Synergism in replication and translation of messenger RNA in a cell-free system.

A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution.

Rod photoreceptor cGMP-phosphodiesterase: analysis of alpha and beta subunits expressed in human kidney cells.

The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1.

Functional complementation of an Escherichia coli ribonuclease H mutation by a cloned genomic fragment from the trypanosomatid Crithidia fasciculata.

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes.

Twist constraints on linker DNA in the 30-nm chromatin fiber: implications for nucleosome phasing.

JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2.

Superfamily Gondwanatherioidea: a previously unrecognized radiation of multituberculate mammals in South America.

Transnuclear retrotransposition of the Tad element of Neurospora.

Identification of additional members of human G-protein-coupled receptor kinase multigene family.

Effects of Mn2+ and Mg2+ on assimilation of NO3- and NH4+ by soil microorganisms.

Reproducing the three-dimensional structure of a tRNA molecule from structural constraints.

Early Cretaceous mammal from North America and the evolution of marsupial dental characters.

Cloning and molecular characterization of a human intracellular serine proteinase inhibitor.

Significant enlargement of a specific subset of CD3+CD8+ peripheral blood leukocytes mediating cytotoxic T-lymphocyte activity during human immunodeficiency virus infection.

K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.

Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.

Bacteriorhodopsin is involved in halobacterial photoreception.

Electromigration behavior of polysaccharides in capillary electrophoresis under pulsed-field conditions.

The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients.

Estrogen receptor and progesterone receptor genes are expressed differentially in mouse embryos during preimplantation development.

High-mobility-group 1 protein mediates DNA bending as determined by ring closures.

Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation.

Identification of a Drosophila activin receptor.

Measurement of the g-tensor of the P700+. signal from deuterated cyanobacterial photosystem I particles.

Chromosomal rearrangement segregating with adrenoleukodystrophy: a molecular analysis.

Chromosomal rearrangement segregating with adrenoleukodystrophy: associated changes in color vision.

Expression of alpha-thymosins in human tissues in normal and abnormal growth.

Molecular characterization of monoclonal CRIA-positive anti-arsonate antibodies derived from idiotype-negative mice bearing a light chain polymorphism.

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

Multiple Ca2+ channel types coexist to regulate synaptosomal neurotransmitter release.

A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.

Herpes simplex virus infected cell polypeptide 4 preferentially represses Sp1-activated over basal transcription from its own promoter.

Purification and characterization of a soluble salicylic acid-binding protein from tobacco.

An accuracy center in the ribosome conserved over 2 billion years.

Peptide nucleic acid (PNA) conformation and polymorphism in PNA-DNA and PNA-RNA hybrids.

Simulation of the kinetics of ligand binding to a protein by molecular dynamics: geminate rebinding of nitric oxide to myoglobin.

Mitochondrial DNA sequence evolution in the Arctoidea.

A single-base-pair mutation changes the specificities of both a transcription activation protein and its binding site.

An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells.

Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells.

The conformation of the sarcin/ricin loop from 28S ribosomal RNA.

Tissue-specific light-regulated expression directed by the promoter of a C4 gene, maize pyruvate,orthophosphate dikinase, in a C3 plant, rice.

Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.

Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fok I endonuclease.

A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.

Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation.

PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect.

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

Single unit components of the hypothalamic multiunit electrical activity associated with the central signal generator that directs the pulsatile secretion of gonadotropic hormones.

[d-Ala2]deltorphin I-like immunoreactivity in the adult rat brain: immunohistochemical localization.

Integrin overexpression induced by high glucose and by human diabetes: potential pathway to cell dysfunction in diabetic microangiopathy.

Cocaine as a naturally occurring insecticide.

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo.

Cloning and expression of a Kv1.2 class delayed rectifier K+ channel from canine colonic smooth muscle.

Soft x-ray magnetic circular dichroism: a probe for studying paramagnetic bioinorganic systems.

Thermal motions and function of bacteriorhodopsin in purple membranes: effects of temperature and hydration studied by neutron scattering.

Cloning and properties of the Caenorhabditis elegans TATA-box-binding protein.

Reconstruction of neural tube-like structures in vitro from primary neural precursor cells.

Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae.

The hobo transposable element of Drosophila can be cross-mobilized in houseflies and excises like the Ac element of maize.

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides.

Molecular dissection of the mouse interleukin-4 promoter.

Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture.

A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4.

Year: 1993 Volume: 90 Issue: 19

Year: 1993 Volume: 90 Issue: 18

Year: 1993 Volume: 90 Issue: 17

Year: 1993 Volume: 90 Issue: 16

Year: 1993 Volume: 90 Issue: 15

Year: 1993 Volume: 90 Issue: 14

Year: 1993 Volume: 90 Issue: 13

Year: 1993 Volume: 90 Issue: 12

Year: 1993 Volume: 90 Issue: 11

Year: 1993 Volume: 90 Issue: 10

Year: 1993 Volume: 90 Issue: 9

Year: 1993 Volume: 90 Issue: 8

Year: 1993 Volume: 90 Issue: 7

Year: 1993 Volume: 90 Issue: 6

Year: 1993 Volume: 90 Issue: 5

Year: 1993 Volume: 90 Issue: 4

Year: 1993 Volume: 90 Issue: 3

Year: 1993 Volume: 90 Issue: 2

Year: 1993 Volume: 90 Issue: 1

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roemer, K. Friedmann, T.
Description	Author Affiliation: Roemer K ( Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0634.);
Abstract	We report that p53her, a chimeric protein consisting of the complete human wild-type p53 and the human estrogen receptor hormone-binding domain, strongly suppresses proliferation and induces characteristic morphological changes in Saos-2 human osteosarcoma cells when induced by 17 beta-estradiol. In contrast, p53her constitutively transactivates a p53-responsive promoter in transfection assays, so that transactivation is not regulated by estradiol. However, coexpression of p53her and oncoprotein MDM-2, which associates with and presumably inactivates p53, results in suppression of p53her-mediated transactivation in the absence, but not the presence, of estradiol. Similarly, p53her induces expression of an endogenous MDM-2 transcript only in the presence of estradiol. These results suggest a correlation between the growth suppressor function of p53her and release of a transactivation block mediated by MDM-2.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Division Gene Expression Regulation Receptors, Estrogen Metabolism Transcription Factors Tumor Suppressor Protein P53 Amino Acid Sequence Estradiol Pharmacology Drug Effects In Vitro Techniques Molecular Sequence Data Recombinant Fusion Proteins Tamoxifen Transcription, Genetic Tumor Cells, Cultured Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in