NDLI: Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

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Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

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Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Leunig, M. Torres Filho, I. P. Yuan, F. Intaglietta, M. Jain, R. K.
Description	Author Affiliation: Torres Filho IP ( Department of Applied Mechanics and Engineering Sciences, University of California, San Diego, La Jolla 92093.);
Abstract	Simultaneous measurements of intravascular and interstitial oxygen partial pressure (PO2) in any tissue have not previously been reported, despite the importance of oxygen in health and in disease. This is due to the limitations of current techniques, both invasive and noninvasive. We have optically measured microscopic profiles of PO2 with high spatial resolution in subcutaneous tissue and transplanted tumors in mice by combining an oxygen-dependent phosphorescence quenching method and a transparent tissue preparation. The strengths of our approach include the ability to follow PO2 in the same location for several weeks and to relate these measurements to local blood flow and vascular architecture. Our results show that (i) PO2 values in blood vessels in well-vascularized regions of a human colon adenocarcinoma xenograft are comparable to those in surrounding arterioles and venules, (ii) carbogen (95% O2/5% CO2) breathing increases microvascular PO2 in tumors, and (iii) in unanesthetized and anesthetized mice PO2 drops to hypoxic values at < 200 microns from isolated vessels but drops by < 5 mmHg (1 mmHg = 133 Pa) in highly vascularized tumor regions. Our method should permit noninvasive evaluations of oxygen-modifying agents and offer further mechanistic information about tumor pathophysiology in tissue preparations where the surface of the tissue can be observed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenocarcinoma Blood Blood Gas Analysis Colonic Neoplasms Oxygen Animals Mice Mice, SCID Neoplasm Transplantation Partial Pressure Tissue Transplantation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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