NDLI: Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.

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Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.

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Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mao, S. Y. Wofsy, C. Metzger, H. Goldstein, B. Kent, U. M. Ross, S.
Description	Author Affiliation: Kent UM ( National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.);
Abstract	Many ligands stimulate cellular responses by aggregating the cell-surface receptors to which they are bound. We investigated several mechanistic questions related to aggregation of receptors by using the high-affinity receptor for IgE (Fc epsilon RI) on mast cells as a model system. We briefly exposed cells to covalently cross-linked oligomers of IgE and then added excess monomeric IgE to prevent further aggregation. Early events were examined by monitoring the phosphorylation of protein tyrosines; later events were examined by monitoring secretion. We found that aggregated receptors continue to signal both late and early events in the absence of formation of new aggregates. Additional experiments suggested that the clustered receptors undergo a dynamic process of phosphorylation and dephosphorylation. Our findings suggest that for these and related receptors that function by aggregation, the persistence of signal transduction is directly related to the intrinsic affinity of the ligand for the individual receptor.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, IgE Physiology Animals Cell Membrane Permeability Edetic Acid Pharmacology In Vitro Techniques Phosphotyrosine Protein-Tyrosine Kinases Metabolism Receptor Aggregation Signal Transduction Tumor Cells, Cultured Tyrosine Analogs & Derivatives Beta-N-Acetylhexosaminidases Secretion Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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