NDLI: Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.

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Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.

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Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gilbert, W. Liu, Z. Lee, A.
Description	Author Affiliation: Liu Z ( Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138-2092, USA.);
Abstract	The yeast gene KEM1 (also named SEP1/DST2/XRN1/RAR5) produces a G4-DNA-dependent nuclease that binds to G4 tetraplex DNA structure and cuts in a single-stranded region 5' to the G4 structure. G4-DNA generated from yeast telomeric oligonucleotides competitively inhibits the cleavage reaction, suggesting that this enzyme may interact with yeast telomeres in vivo. Homozygous deletions of the KEM1 gene in yeast block meiosis at the pachytene stage, which is consistent with the hypothesis that G4 tetraplex DNA may be involved in homologous chromosome pairing during meiosis. We conjectured that the mitotic defects of kem1/sep1 mutant cells, such as a higher chromosome loss rate, are also due to failure in processing G4-DNA, especially at telomeres. Here we report two phenotypes associated with a kem1-null allele, cellular senescence and telomere shortening, that provide genetic evidence that G4 tetraplex DNA may play a role in telomere functioning. In addition, our results reveal that chromosome ends in the same cells behave differently in a fashion dependent on the KEM1 gene product.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Deoxyribonucleases Biosynthesis Genetics Exoribonucleases Fungal Proteins Genes, Fungal Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Telomere Physiology Blotting, Southern DNA, Fungal Isolation & Purification Drug Effects Oligodeoxyribonucleotides Pharmacology Phenotype Plasmids Restriction Mapping Cytology Growth & Development Ultrastructure Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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